{"created":"2023-06-26T11:01:06.160494+00:00","id":1720,"links":{},"metadata":{"_buckets":{"deposit":"f5fc7000-dd94-4371-ad68-78bfd5fb7ef6"},"_deposit":{"created_by":30,"id":"1720","owners":[30],"pid":{"revision_id":0,"type":"depid","value":"1720"},"status":"published"},"_oai":{"id":"oai:oist.repo.nii.ac.jp:00001720","sets":["6:73"]},"author_link":["10342","10341","10343","10344"],"item_10001_biblio_info_7":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-07-16","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"220","bibliographicVolumeNumber":"14","bibliographic_titles":[{},{"bibliographic_title":"Frontiers in Cellular Neuroscience","bibliographic_titleLang":"en"}]}]},"item_10001_creator_3":{"attribute_name":"Author","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ackels, Tobias"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Jordan, Rebecca"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Schaefer, Andreas T."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fukunaga, Izumi"}],"nameIdentifiers":[{}]}]},"item_10001_description_5":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"For sensory systems of the brain, the dynamics of an animal’s own sampling behavior has a direct consequence on ensuing computations. This is particularly the case for mammalian olfaction, where a rhythmic flow of air over the nasal epithelium entrains activity in olfactory system neurons in a phenomenon known as sniff-locking. Parameters of sniffing can, however, change drastically with brain states. Coupled to the fact that different observation methods have different kinetics, consensus on the sniff-locking properties of neurons is lacking. To address this, we investigated the sniff-related activity of olfactory sensory neurons (OSNs), as well as the principal neurons of the olfactory bulb (OB), using 2-photon calcium imaging and intracellular whole-cell patch-clamp recordings in vivo, both in anesthetized and awake mice. Our results indicate that OSNs and OB output neurons lock robustly to the sniff rhythm, but with a slight temporal shift between behavioral states. We also observed a slight delay between methods. Further, the divergent sniff-locking by tufted cells (TCs) and mitral cells (MCs) in the absence of odor can be used to determine the cell type reliably using a simple linear classifier. Using this classification on datasets where morphological identification is unavailable, we find that MCs use a wider range of temporal shifts to encode odors than previously thought, while TCs have a constrained timing of activation due to an early-onset hyperpolarization. We conclude that the sniff rhythm serves as a fundamental rhythm but its impact on odor encoding depends on cell type, and this difference is accentuated in awake mice.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Frontiers Media "}]},"item_10001_relation_13":{"attribute_name":"PubMedNo.","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:pmid/32765224","subitem_relation_type_select":"PMID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.3389/fncel.2020.00220","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_17":{"attribute_name":"Related site","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.frontiersin.org/articles/10.3389/fncel.2020.00220/full","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"© 2020 Ackels, Jordan, Schaefer and Fukunaga."}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1662-5102","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"Author's flag","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-10-14"}],"displaytype":"detail","filename":"Ackels-2020-Respiration-Locking of Olfactory R.pdf","filesize":[{"value":"7.0 MB"}],"format":"application/pdf","license_note":"Creative Commons Attribution 4.0 International(https://creativecommons.org/licenses/by/4.0/)","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Ackels-2020-Respiration-Locking of Olfactory R","url":"https://oist.repo.nii.ac.jp/record/1720/files/Ackels-2020-Respiration-Locking of Olfactory R.pdf"},"version_id":"c3ec67f5-c1ba-4c85-9dc5-ac85b48b8154"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"olfaction","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"temporal coding","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"olfactory bulb","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"imaging","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"electrophysiology","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"active sampling","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Respiration-Locking of Olfactory Receptor and Projection Neurons in the Mouse Olfactory Bulb and Its Modulation by Brain State","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Respiration-Locking of Olfactory Receptor and Projection Neurons in the Mouse Olfactory Bulb and Its Modulation by Brain State","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"30","path":["73"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-10-14"},"publish_date":"2020-10-14","publish_status":"0","recid":"1720","relation_version_is_last":true,"title":["Respiration-Locking of Olfactory Receptor and Projection Neurons in the Mouse Olfactory Bulb and Its Modulation by Brain State"],"weko_creator_id":"30","weko_shared_id":30},"updated":"2023-06-26T11:43:58.054361+00:00"}