{"created":"2023-06-26T11:01:07.710203+00:00","id":1746,"links":{},"metadata":{"_buckets":{"deposit":"1cdc2665-0ba7-4eec-a8b1-5faa1d909be1"},"_deposit":{"created_by":28,"id":"1746","owners":[28],"pid":{"revision_id":0,"type":"depid","value":"1746"},"status":"published"},"_oai":{"id":"oai:oist.repo.nii.ac.jp:00001746","sets":["6:63"]},"author_link":["10490","10491"],"item_10001_biblio_info_7":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-08-20","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"37","bibliographicPageEnd":"41112","bibliographicPageStart":"41105","bibliographicVolumeNumber":"12","bibliographic_titles":[{},{"bibliographic_title":"ACS Applied Materials & Interfaces","bibliographic_titleLang":"en"}]}]},"item_10001_creator_3":{"attribute_name":"Author","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Zhang, Shijin"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Zhang, Ye"}],"nameIdentifiers":[{}]}]},"item_10001_description_5":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"Despite the promise of nanomedicine in the fight against complex diseases, the enthusiasm for its pharmaceutical development is backed by the elevated costs associated with the R&D process. Therefore, as a compromise solution, nanotechnology was mainly applied as a drug delivery system to improve bioavailability and controllability of pharmaceutical drugs. Attempting to break the restrictions without elevating potential costs, we multiply the functions of excipients in the nanodelivery system by endowing subcellular-targeting ability. To prove the concept, fluorescent endoplasmic reticulum-targeted short peptides were covalently connected to chemotherapy medication chlorambucil achieving enhanced drug-loading efficiency. Via visualized intracellular dynamic enzyme-catalyzed hydrolysis, the ER-targeting excipient and nucleus-targeting chlorambucil are released simultaneously, achieving a synergistic anticancer effect and elucidating the influence of intracellular self-assembly transition on enzymatic reactions.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"American Chemical Society"}]},"item_10001_relation_13":{"attribute_name":"PubMedNo.","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:pmid/32819089","subitem_relation_type_select":"PMID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1021/acsami.0c12271","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_17":{"attribute_name":"Related site","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://pubs.acs.org/doi/10.1021/acsami.0c12271","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"© 2020 American Chemical Society"},{"subitem_rights":"This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Applied Materials & Interfaces, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acsami.0c12271"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1944-8244","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"1944-8252","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"Author's flag","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-08-20"}],"displaytype":"detail","filename":"ami-2020.pdf","filesize":[{"value":"5.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ami-2020","url":"https://oist.repo.nii.ac.jp/record/1746/files/ami-2020.pdf"},"version_id":"4c9b743a-566d-40d3-bdfe-96766a7d83c0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"dual-targeting","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"instructed self-assembly","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"anticancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"chlorambucil","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ER stress","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Promoting Dual-Targeting Anticancer Effect by Regulating the Dynamic Intracellular Self-Assembly","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Promoting Dual-Targeting Anticancer Effect by Regulating the Dynamic Intracellular Self-Assembly","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"28","path":["63"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-10-29"},"publish_date":"2020-10-29","publish_status":"0","recid":"1746","relation_version_is_last":true,"title":["Promoting Dual-Targeting Anticancer Effect by Regulating the Dynamic Intracellular Self-Assembly"],"weko_creator_id":"28","weko_shared_id":28},"updated":"2023-06-26T11:43:07.599003+00:00"}