{"created":"2023-06-26T11:01:09.307726+00:00","id":1777,"links":{},"metadata":{"_buckets":{"deposit":"53a16266-b161-456e-920c-bf5de5dbb02a"},"_deposit":{"created_by":30,"id":"1777","owners":[30],"pid":{"revision_id":0,"type":"depid","value":"1777"},"status":"published"},"_oai":{"id":"oai:oist.repo.nii.ac.jp:00001777","sets":["6:221"]},"author_link":["10678","10684","10680","10679","10687","10685","10681","10683","10686","10682"],"item_10001_biblio_info_7":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-09-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"17","bibliographicPageEnd":"3469.e4","bibliographicPageStart":"3465","bibliographicVolumeNumber":"30","bibliographic_titles":[{},{"bibliographic_title":"Current Biology","bibliographic_titleLang":"en"}]}]},"item_10001_creator_3":{"attribute_name":"Author","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Zeberg, Hugo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Dannemann, Michael"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sahlholm, Kristoffer"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsuo, Kristin"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Maricic, Tomislav"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Wiebe, Victor"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hevers, Wulf"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Robinson, Hugh P.C."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kelso, Janet"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Pääbo, Svante"}],"nameIdentifiers":[{}]}]},"item_10001_description_5":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"The sodium channel Nav1.7 is crucial for impulse generation and conduction in peripheral pain pathways [1]. In Neanderthals, the Nav1.7 protein carried three amino acid substitutions (M932L, V991L, and D1908G) relative to modern humans. We expressed Nav1.7 proteins carrying all combinations of these substitutions and studied their electrophysiological effects. Whereas the single amino acid substitutions do not affect the function of the ion channel, the full Neanderthal variant carrying all three substitutions, as well as the combination of V991L with D1908G, shows reduced inactivation, suggesting that peripheral nerves were more sensitive to painful stimuli in Neanderthals than in modern humans. We show that, due to gene flow from Neanderthals, the three Neanderthal substitutions are found in approximately 0.4% of present-day Britons, where they are associated with heightened pain sensitivity.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Elsevier Inc"}]},"item_10001_relation_13":{"attribute_name":"PubMedNo.","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:pmid/32707058","subitem_relation_type_select":"PMID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1016/j.cub.2020.06.045","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_17":{"attribute_name":"Related site","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.sciencedirect.com/science/article/pii/S0960982220308617?via%3Dihub","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"© 2020 The Author(s)"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0960-9822","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"1879-0445","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"Author's flag","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-11-16"}],"displaytype":"detail","filename":"1-s2.0-S0960982220308617-main.pdf","filesize":[{"value":"1.4 MB"}],"format":"application/pdf","license_note":"Creative Commons Attribution 4.0 International(https://creativecommons.org/licenses/by/4.0/)","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"1-s2.0-S0960982220308617-main","url":"https://oist.repo.nii.ac.jp/record/1777/files/1-s2.0-S0960982220308617-main.pdf"},"version_id":"3e19f908-37a7-47c2-aed1-b9cde5bbb7c5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Neanderthals","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"sodium channel","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"pain","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"introgression","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"gene flow","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A Neanderthal Sodium Channel Increases Pain Sensitivity in Present-Day Humans","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A Neanderthal Sodium Channel Increases Pain Sensitivity in Present-Day Humans","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"30","path":["221"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-11-16"},"publish_date":"2020-11-16","publish_status":"0","recid":"1777","relation_version_is_last":true,"title":["A Neanderthal Sodium Channel Increases Pain Sensitivity in Present-Day Humans"],"weko_creator_id":"30","weko_shared_id":30},"updated":"2023-07-31T03:43:02.667402+00:00"}