{"created":"2023-06-26T11:01:09.517065+00:00","id":1785,"links":{},"metadata":{"_buckets":{"deposit":"2b8c859d-5be0-45ab-90c4-4a8088b20ce0"},"_deposit":{"created_by":30,"id":"1785","owners":[30],"pid":{"revision_id":0,"type":"depid","value":"1785"},"status":"published"},"_oai":{"id":"oai:oist.repo.nii.ac.jp:00001785","sets":["6:40"]},"author_link":["10703","10696","10695","10700","10704","10698","10701","10697","10699","10702"],"item_10001_biblio_info_7":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-09-09","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"001491","bibliographic_titles":[{},{"bibliographic_title":"Journal of General Virology","bibliographic_titleLang":"en"}]}]},"item_10001_creator_3":{"attribute_name":"Author","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Banerjee, Arinjay"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Doxey, Andrew C."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tremblay, Benjamin J.-M."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mansfield, Michael J."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Subudhi, Sonu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hirota, Jeremy A."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miller, Matthew S."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"McArthur, Andrew G."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mubareka, Samira"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mossman, Karen"}],"nameIdentifiers":[{}]}]},"item_10001_description_5":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) recently emerged to cause widespread infections in humans. SARS-CoV-2 infections have been reported in the Kingdom of Saudi Arabia, where Middle East respiratory syndrome coronavirus (MERS-CoV) causes seasonal outbreaks with a case fatality rate of ~37 %. Here we show that there exists a theoretical possibility of future recombination events between SARS-CoV-2 and MERS-CoV RNA. Through computational analyses, we have identified homologous genomic regions within the ORF1ab and S genes that could facilitate recombination, and have analysed co-expression patterns of the cellular receptors for SARS-CoV-2 and MERS-CoV, ACE2 and DPP4, respectively, to identify human anatomical sites that could facilitate co-infection. Furthermore, we have investigated the likely susceptibility of various animal species to MERS-CoV and SARS-CoV-2 infection by comparing known virus spike protein–receptor interacting residues. In conclusion, we suggest that a recombination between SARS-CoV-2 and MERS-CoV RNA is possible and urge public health laboratories in high-risk areas to develop diagnostic capability for the detection of recombined coronaviruses in patient samples.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Microbiology Society "}]},"item_10001_relation_13":{"attribute_name":"PubMedNo.","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:pmid/32902372","subitem_relation_type_select":"PMID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1099/jgv.0.001491","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_17":{"attribute_name":"Related site","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.microbiologyresearch.org/content/journal/jgv/10.1099/jgv.0.001491","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"© 2020 The Author(s)"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0022-1317","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"1465-2099","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"Author's flag","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-11-16"}],"displaytype":"detail","filename":"jgv001491.pdf","filesize":[{"value":"3.8 MB"}],"format":"application/pdf","license_note":"Creative Commons Attribution 4.0 International(https://creativecommons.org/licenses/by/4.0/)","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"jgv001491","url":"https://oist.repo.nii.ac.jp/record/1785/files/jgv001491.pdf"},"version_id":"ad67d5ee-71b9-4261-96f6-f2ad77f0b37c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"coronavirus","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"SARS-CoV-2","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"MERS-CoV","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"recombination","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"emergence","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"predictions","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"COVID-19","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Predicting the recombination potential of severe acute respiratory syndrome coronavirus 2 and Middle East respiratory syndrome coronavirus","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Predicting the recombination potential of severe acute respiratory syndrome coronavirus 2 and Middle East respiratory syndrome coronavirus","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"30","path":["40"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-11-16"},"publish_date":"2020-11-16","publish_status":"0","recid":"1785","relation_version_is_last":true,"title":["Predicting the recombination potential of severe acute respiratory syndrome coronavirus 2 and Middle East respiratory syndrome coronavirus"],"weko_creator_id":"30","weko_shared_id":30},"updated":"2023-06-26T11:42:56.644862+00:00"}