{"created":"2023-06-26T11:01:09.662191+00:00","id":1788,"links":{},"metadata":{"_buckets":{"deposit":"f9645101-cd5a-4735-a19a-89a419d6935e"},"_deposit":{"created_by":30,"id":"1788","owners":[30],"pid":{"revision_id":0,"type":"depid","value":"1788"},"status":"published"},"_oai":{"id":"oai:oist.repo.nii.ac.jp:00001788","sets":["6:25"]},"author_link":["10719","10721","10720"],"item_10001_biblio_info_7":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-09-08","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"e60692","bibliographicVolumeNumber":"9","bibliographic_titles":[{},{"bibliographic_title":"eLife","bibliographic_titleLang":"en"}]}]},"item_10001_creator_3":{"attribute_name":"Author","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Zang, Yunliang"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hong, Sungho"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"De Schutter, Erik"}],"nameIdentifiers":[{}]}]},"item_10001_description_5":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"Both spike rate and timing can transmit information in the brain. Phase response curves (PRCs) quantify how a neuron transforms input to output by spike timing. PRCs exhibit strong firing-rate adaptation, but its mechanism and relevance for network output are poorly understood. Using our Purkinje cell (PC) model, we demonstrate that the rate adaptation is caused by rate-dependent subthreshold membrane potentials efficiently regulating the activation of Na(+) channels. Then, we use a realistic PC network model to examine how rate-dependent responses synchronize spikes in the scenario of reciprocal inhibition-caused high-frequency oscillations. The changes in PRC cause oscillations and spike correlations only at high firing rates. The causal role of the PRC is confirmed using a simpler coupled oscillator network model. This mechanism enables transient oscillations between fast-spiking neurons that thereby form PC assemblies. Our work demonstrates that rate adaptation of PRCs can spatio-temporally organize the PC input to cerebellar nuclei.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"eLife Sciences Publications "}]},"item_10001_relation_13":{"attribute_name":"PubMedNo.","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:pmid/32895121","subitem_relation_type_select":"PMID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.7554/eLife.60692","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_17":{"attribute_name":"Related site","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://elifesciences.org/articles/60692","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"© 2020 Zang et al."}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2050-084X","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"Author's flag","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-11-16"}],"displaytype":"detail","filename":"elife-60692-v1.pdf","filesize":[{"value":"2.4 MB"}],"format":"application/pdf","license_note":"Creative Commons Attribution 4.0 International(https://creativecommons.org/licenses/by/4.0/)","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"elife-60692-v1","url":"https://oist.repo.nii.ac.jp/record/1788/files/elife-60692-v1.pdf"},"version_id":"2441d572-a115-4b05-98b5-100ee452af66"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Purkinje cell","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"phase response curve","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"rate adaptation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"reciprocal inhibition","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"network oscillations","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"transient assembly","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Firing rate-dependent phase responses of Purkinje cells support transient oscillations","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Firing rate-dependent phase responses of Purkinje cells support transient oscillations","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"30","path":["25"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-11-16"},"publish_date":"2020-11-16","publish_status":"0","recid":"1788","relation_version_is_last":true,"title":["Firing rate-dependent phase responses of Purkinje cells support transient oscillations"],"weko_creator_id":"30","weko_shared_id":30},"updated":"2023-06-26T11:42:53.803494+00:00"}