{"created":"2023-06-26T11:01:12.026132+00:00","id":1844,"links":{},"metadata":{"_buckets":{"deposit":"47d70354-0dc6-4095-a2eb-1454f3179902"},"_deposit":{"created_by":30,"id":"1844","owners":[30],"pid":{"revision_id":0,"type":"depid","value":"1844"},"status":"published"},"_oai":{"id":"oai:oist.repo.nii.ac.jp:00001844","sets":["6:67"]},"author_link":["11017","11018","11019","11013","11022","11014","11021","11023","11015","11020","11016"],"item_10001_biblio_info_7":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-12-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"23","bibliographicPageStart":"9319","bibliographicVolumeNumber":"21","bibliographic_titles":[{},{"bibliographic_title":"International Journal of Molecular Sciences","bibliographic_titleLang":"en"}]}]},"item_10001_creator_3":{"attribute_name":"Author","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Suzuki, Toru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Adachi, Shungo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kikuguchi, Chisato"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shibata, Shinsuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nishijima, Saori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawamoto, Yurie"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Iizuka, Yusuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Koseki, Haruhiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okano, Hideyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Natsume, Tohru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamamoto, Tadashi"}],"nameIdentifiers":[{}]}]},"item_10001_description_5":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"Transcripts of alpha-fetoprotein (Afp), H19, and insulin-like growth factor 2 (Igf2) genes are highly expressed in mouse fetal liver, but decrease drastically during maturation. While transcriptional regulation of these genes has been well studied, the post-transcriptional regulation of their developmental decrease is poorly understood. Here, we show that shortening of poly(A) tails and subsequent RNA decay are largely responsible for the postnatal decrease of Afp, H19, and Igf2 transcripts in mouse liver. IGF2 mRNA binding protein 1 (IMP1), which regulates stability and translation efficiency of target mRNAs, binds to these fetal liver transcripts. When IMP1 is exogenously expressed in mouse adult liver, fetal liver transcripts show higher expression and possess longer poly(A) tails, suggesting that IMP1 stabilizes them. IMP1 declines concomitantly with fetal liver transcripts as liver matures. Instead, RNA-binding proteins (RBPs) that promote RNA decay, such as cold shock domain containing protein E1 (CSDE1), K-homology domain splicing regulatory protein (KSRP), and CUG-BP1 and ETR3-like factors 1 (CELF1), bind to 3′ regions of fetal liver transcripts. These data suggest that transitions among RBPs associated with fetal liver transcripts shift regulation from stabilization to decay, leading to a postnatal decrease in those fetal transcripts.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"MDPI"}]},"item_10001_relation_13":{"attribute_name":"PubMedNo.","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:pmid/33297405","subitem_relation_type_select":"PMID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.3390/ijms21239319","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_17":{"attribute_name":"Related site","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.mdpi.com/1422-0067/21/23/9319","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"© 2020 The Author(s)."}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1422-0067","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"1661-6596","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"Author's flag","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-14"}],"displaytype":"detail","filename":"Suzuki-2020-Regulation of Fetal Genes by Trans.pdf","filesize":[{"value":"2.2 MB"}],"format":"application/pdf","license_note":"Creative Commons Attribution 4.0 International(https://creativecommons.org/licenses/by/4.0/)","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Suzuki-2020-Regulation of Fetal Genes by Trans","url":"https://oist.repo.nii.ac.jp/record/1844/files/Suzuki-2020-Regulation of Fetal Genes by Trans.pdf"},"version_id":"b4699cde-c0a4-46e2-bd99-40d0f821c48c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"RNA binding proteins","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"fetal liver genes","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ccr4-not complex","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Regulation of Fetal Genes by Transitions among RNA-Binding Proteins during Liver Development","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Regulation of Fetal Genes by Transitions among RNA-Binding Proteins during Liver Development","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"30","path":["67"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-12-14"},"publish_date":"2020-12-14","publish_status":"0","recid":"1844","relation_version_is_last":true,"title":["Regulation of Fetal Genes by Transitions among RNA-Binding Proteins during Liver Development"],"weko_creator_id":"30","weko_shared_id":30},"updated":"2023-06-26T11:41:40.655158+00:00"}