@article{oai:oist.repo.nii.ac.jp:00001857, author = {Keating, Sarah M and Waltemath, Dagmar and König, Matthias and Zhang, Fengkai and Dräger, Andreas and Chaouiya, Claudine and Bergmann, Frank T and Finney, Andrew and Gillespie, Colin S and Helikar, Tomáš and Hoops, Stefan and Malik‐Sheriff, Rahuman S and Moodie, Stuart L and Moraru, Ion I and Myers, Chris J and Naldi, Aurélien and Olivier, Brett G and Sahle, Sven and Schaff, James C and Smith, Lucian P and Swat, Maciej J and Thieffry, Denis and Watanabe, Leandro and Wilkinson, Darren J and Blinov, Michael L and Begley, Kimberly and Faeder, James R and Gómez, Harold F and Hamm, Thomas M and Inagaki, Yuichiro and Liebermeister, Wolfram and Lister, Allyson L and Lucio, Daniel and Mjolsness, Eric and Proctor, Carole J and Raman, Karthik and Rodriguez, Nicolas and Shaffer, Clifford A and Shapiro, Bruce E and Stelling, Joerg and Swainston, Neil and Tanimura, Naoki and Wagner, John and Meier‐Schellersheim, Martin and Sauro, Herbert M and Palsson, Bernhard and Bolouri, Hamid and Kitano, Hiroaki and Funahashi, Akira and Hermjakob, Henning and Doyle, John C and Hucka, Michael and Adams, Richard R and Allen, Nicholas A and Angermann, Bastian R and Antoniotti, Marco and Bader, Gary D and Červený, Jan and Courtot, Mélanie and Cox, Chris D and Dalle Pezze, Piero and Demir, Emek and Denney, William S and Dharuri, Harish and Dorier, Julien and Drasdo, Dirk and Ebrahim, Ali and Eichner, Johannes and Elf, Johan and Endler, Lukas and Evelo, Chris T and Flamm, Christoph and Fleming, Ronan MT and Fröhlich, Martina and Glont, Mihai and Gonçalves, Emanuel and Golebiewski, Martin and Grabski, Hovakim and Gutteridge, Alex and Hachmeister, Damon and Harris, Leonard A and Heavner, Benjamin D and Henkel, Ron and Hlavacek, William S and Hu, Bin and Hyduke, Daniel R and Jong, Hidde and Juty, Nick and Karp, Peter D and Karr, Jonathan R and Kell, Douglas B and Keller, Roland and Kiselev, Ilya and Klamt, Steffen and Klipp, Edda and Knüpfer, Christian and Kolpakov, Fedor and Krause, Falko and Kutmon, Martina and Laibe, Camille and Lawless, Conor and Li, Lu and Loew, Leslie M and Machne, Rainer and Matsuoka, Yukiko and Mendes, Pedro and Mi, Huaiyu and Mittag, Florian and Monteiro, Pedro T and Natarajan, Kedar Nath and Nielsen, Poul MF and Nguyen, Tramy and Palmisano, Alida and Pettit, Jean‐Baptiste and Pfau, Thomas and Phair, Robert D and Radivoyevitch, Tomas and Rohwer, Johann M and Ruebenacker, Oliver A and Saez‐Rodriguez, Julio and Scharm, Martin and Schmidt, Henning and Schreiber, Falk and Schubert, Michael and Schulte, Roman and Sealfon, Stuart C and Smallbone, Kieran and Soliman, Sylvain and Stefan, Melanie I and Sullivan, Devin P and Takahashi, Koichi and Teusink, Bas and Tolnay, David and Vazirabad, Ibrahim and Kamp, Axel and Wittig, Ulrike and Wrzodek, Clemens and Wrzodek, Finja and Xenarios, Ioannis and Yamada, Takahiro G and Zhukova, Anna and Zucker, Jeremy}, issue = {8}, journal = {Molecular Systems Biology}, month = {Aug}, note = {Systems biology has experienced dramatic growth in the number, size, and complexity of computational models. To reproduce simulation results and reuse models, researchers must exchange unambiguous model descriptions. We review the latest edition of the Systems Biology Markup Language (SBML), a format designed for this purpose. A community of modelers and software authors developed SBML Level 3 over the past decade. Its modular form consists of a core suited to representing reaction-based models and packages that extend the core with features suited to other model types including constraint-based models, reaction-diffusion models, logical network models, and rule-based models. The format leverages two decades of SBML and a rich software ecosystem that transformed how systems biologists build and interact with models. More recently, the rise of multiscale models of whole cells and organs, and new data sources such as single-cell measurements and live imaging, has precipitated new ways of integrating data with models. We provide our perspectives on the challenges presented by these developments and how SBML Level 3 provides the foundation needed to support this evolution.}, title = {SBML Level 3: an extensible format for the exchange and reuse of biological models}, volume = {16}, year = {2020} }