{"created":"2023-06-26T11:01:13.188159+00:00","id":1877,"links":{},"metadata":{"_buckets":{"deposit":"1ba893d0-c6a9-4452-b6b9-13715aa20a12"},"_deposit":{"created_by":30,"id":"1877","owners":[30],"pid":{"revision_id":0,"type":"depid","value":"1877"},"status":"published"},"_oai":{"id":"oai:oist.repo.nii.ac.jp:00001877","sets":["6:66"]},"author_link":["12007","12009","12008"],"item_10001_biblio_info_7":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-10-21","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageEnd":"733","bibliographicPageStart":"720","bibliographicVolumeNumber":"2","bibliographic_titles":[{},{"bibliographic_title":"FASEB BioAdvances","bibliographic_titleLang":"en"}]}]},"item_10001_creator_3":{"attribute_name":"Author","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Teruya, Takayuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Goga, Haruhisa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yanagida, Mitsuhiro"}],"nameIdentifiers":[{}]}]},"item_10001_description_5":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"Metabolites in human biofluids document the physiological status of individuals. We conducted comprehensive, non‐targeted, non‐invasive metabolomic analysis of urine from 27 healthy human subjects, comprising 13 young adults (30 ± 3 years) and 14 seniors (76 ± 4 years). Quantitative analysis of 99 metabolites revealed 55 that displayed significant differences in abundance between the two groups. Forty‐four did not show a statistically significant relationship with age. These include 13 standard amino acids, 5 methylated, 4 acetylated, and 9 other amino acids, 6 nucleosides, nucleobases, and derivatives, 4 sugar derivatives, 5 sugar phosphates, 4 carnitines, 2 hydroxybutyrates, 1 choline, and 1 ethanolamine derivative, and glutathione disulfide. Abundances of 53 compounds decreased, while 2 (glutathione disulfide, myo‐inositol) increased in elderly people. The great majority of age‐linked markers were highly correlated with creatinine. In contrast, 44 other urinary metabolites, including urate, carnitine, hippurate, and betaine, were not age‐linked, neither declining nor increasing in elderly subjects. As metabolite profiles of urine and blood are quite different, age‐related information in urine offers additional valuable insights into aging mechanisms of endocrine system. Correlation analysis of urinary metabolites revealed distinctly inter‐related groups of compounds.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Federation of American Societies for Experimental Biology."}]},"item_10001_relation_13":{"attribute_name":"PubMedNo.","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:pmid/33336159","subitem_relation_type_select":"PMID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1096/fba.2020-00047","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_17":{"attribute_name":"Related site","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://faseb.onlinelibrary.wiley.com/doi/10.1096/fba.2020-00047","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"© 2020 The Author(s)."}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2573-9832","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"Author's flag","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-01-15"}],"displaytype":"detail","filename":"fba.2020-00047.pdf","filesize":[{"value":"1.4 MB"}],"format":"application/pdf","license_note":"Creative Commons Attribution-NonCommercial 4.0 International(https://creativecommons.org/licenses/by-nc/4.0/)","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"fba.2020-00047","url":"https://oist.repo.nii.ac.jp/record/1877/files/fba.2020-00047.pdf"},"version_id":"b5372028-a840-4cf2-bd87-0de040bd4113"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"creatinine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"glutathione","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"human endocrine aging","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"LC-MS","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"non-targeted metabolomics","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"pseudouridine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"urinary age markers","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Aging markers in human urine: A comprehensive, non‐targeted LC‐MS study","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Aging markers in human urine: A comprehensive, non‐targeted LC‐MS study","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"30","path":["66"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-01-15"},"publish_date":"2021-01-15","publish_status":"0","recid":"1877","relation_version_is_last":true,"title":["Aging markers in human urine: A comprehensive, non‐targeted LC‐MS study"],"weko_creator_id":"30","weko_shared_id":30},"updated":"2023-06-26T11:41:07.078678+00:00"}