@article{oai:oist.repo.nii.ac.jp:00001921,
 author = {Kondoh, Hiroshi and Kameda, Masahiro and Yanagida, Mitsuhiro},
 issue = {1},
 journal = {International Journal of Molecular Sciences},
 month = {Dec},
 note = {Diversity is observed in the wave of global aging because it is a complex biological process exhibiting individual variability. To assess aging physiologically, markers for biological aging are required in addition to the calendar age. From a metabolic perspective, the aging hypothesis includes the mitochondrial hypothesis and the calorie restriction (CR) hypothesis. In experimental models, several compounds or metabolites exert similar lifespan-extending effects, like CR. However, little is known about whether these metabolic modulations are applicable to human longevity, as human aging is greatly affected by a variety of factors, including lifestyle, genetic or epigenetic factors, exposure to stress, diet, and social environment. A comprehensive analysis of the human blood metabolome captures complex changes with individual differences. Moreover, a non-targeted analysis of the whole blood metabolome discloses unexpected aspects of human biology. By using such approaches, markers for aging or aging-relevant conditions were identified. This information should prove valuable for future diagnosis or clinical interventions in diseases relevant to aging.},
 title = {Whole Blood Metabolomics in Aging Research},
 volume = {22},
 year = {2020}
}