{"created":"2023-06-26T11:01:15.439416+00:00","id":1921,"links":{},"metadata":{"_buckets":{"deposit":"e20fa07d-2fa5-4919-97df-e92a9e7dab9b"},"_deposit":{"created_by":30,"id":"1921","owners":[30],"pid":{"revision_id":0,"type":"depid","value":"1921"},"status":"published"},"_oai":{"id":"oai:oist.repo.nii.ac.jp:00001921","sets":["6:66"]},"author_link":["12651","12653","12652"],"item_10001_biblio_info_7":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-12-26","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageStart":"175","bibliographicVolumeNumber":"22","bibliographic_titles":[{},{"bibliographic_title":"International Journal of Molecular Sciences","bibliographic_titleLang":"en"}]}]},"item_10001_creator_3":{"attribute_name":"Author","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kondoh, Hiroshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kameda, Masahiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yanagida, Mitsuhiro"}],"nameIdentifiers":[{}]}]},"item_10001_description_5":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"Diversity is observed in the wave of global aging because it is a complex biological process exhibiting individual variability. To assess aging physiologically, markers for biological aging are required in addition to the calendar age. From a metabolic perspective, the aging hypothesis includes the mitochondrial hypothesis and the calorie restriction (CR) hypothesis. In experimental models, several compounds or metabolites exert similar lifespan-extending effects, like CR. However, little is known about whether these metabolic modulations are applicable to human longevity, as human aging is greatly affected by a variety of factors, including lifestyle, genetic or epigenetic factors, exposure to stress, diet, and social environment. A comprehensive analysis of the human blood metabolome captures complex changes with individual differences. Moreover, a non-targeted analysis of the whole blood metabolome discloses unexpected aspects of human biology. By using such approaches, markers for aging or aging-relevant conditions were identified. This information should prove valuable for future diagnosis or clinical interventions in diseases relevant to aging.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"MDPI "}]},"item_10001_relation_13":{"attribute_name":"PubMedNo.","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:pmid/33375345","subitem_relation_type_select":"PMID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.3390/ijms22010175","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_17":{"attribute_name":"Related site","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.mdpi.com/1422-0067/22/1/175","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"© 2020 The Author(s)."}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1422-0067","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"1661-6596","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"Author's flag","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-02-05"}],"displaytype":"detail","filename":"Kondoh-2021-Whole Blood Metabolomics in Aging.pdf","filesize":[{"value":"1.5 MB"}],"format":"application/pdf","license_note":"Creative Commons Attribution 4.0 International(https://creativecommons.org/licenses/by/4.0/)","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Kondoh-2021-Whole Blood Metabolomics in Aging","url":"https://oist.repo.nii.ac.jp/record/1921/files/Kondoh-2021-Whole Blood Metabolomics in Aging.pdf"},"version_id":"639bd393-98ae-4e93-9fbb-22ba99e90d3c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"aging","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"metabolites","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"frailty","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"fasting","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"antioxidant","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"metabolomics","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"whole blood","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Whole Blood Metabolomics in Aging Research","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Whole Blood Metabolomics in Aging Research","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"30","path":["66"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-02-05"},"publish_date":"2021-02-05","publish_status":"0","recid":"1921","relation_version_is_last":true,"title":["Whole Blood Metabolomics in Aging Research"],"weko_creator_id":"30","weko_shared_id":30},"updated":"2023-06-26T11:32:44.774946+00:00"}