@article{oai:oist.repo.nii.ac.jp:00001981,
 author = {Ito-Kureha, Taku and Miyao, Takahisa and Nishijima, Saori and Suzuki, Toru and Koizumi, Shin-ichi and Villar-Briones, Alejandro and Takahashi, Akinori and Akiyama, Nobuko and Morita, Masahiro and Naguro, Isao and Ishikawa, Hiroki and Ichijo, Hidenori and Akiyama, Taishin and Yamamoto, Tadashi},
 issue = {1},
 journal = {Nature Communications},
 month = {Dec},
 note = {A repertoire of T cells with diverse antigen receptors is selected in the thymus. However, detailed mechanisms underlying this thymic positive selection are not clear. Here we show that the CCR4-NOT complex limits expression of specific genes through deadenylation of mRNA poly(A) tails, enabling positive selection. Specifically, the CCR4-NOT complex is up-regulated in thymocytes before initiation of positive selection, where in turn, it inhibits up-regulation of pro-apoptotic Bbc3 and Dab2ip. Elimination of the CCR4-NOT complex permits up-regulation of Bbc3 during a later stage of positive selection, inducing thymocyte apoptosis. In addition, CCR4-NOT elimination up-regulates Dab2ip at an early stage of positive selection. Thus, CCR4-NOT might control thymocyte survival during two-distinct stages of positive selection by suppressing expression levels of pro-apoptotic molecules. Taken together, we propose a link between CCR4-NOT-mediated mRNA decay and T cell selection in the thymus.},
 title = {The CCR4–NOT deadenylase complex safeguards thymic positive selection by down-regulating aberrant pro-apoptotic gene expression},
 volume = {11},
 year = {2020}
}