{"created":"2023-06-26T11:01:18.343235+00:00","id":1981,"links":{},"metadata":{"_buckets":{"deposit":"d673d06f-f258-4724-90fb-7f83e7f63314"},"_deposit":{"created_by":28,"id":"1981","owners":[28],"pid":{"revision_id":0,"type":"depid","value":"1981"},"status":"published"},"_oai":{"id":"oai:oist.repo.nii.ac.jp:00001981","sets":["6:167","6:33","6:67"]},"author_link":["12985","12977","12986","12982","12978","12984","12988","12987","12976","12989","12983","12979","12980","12981"],"item_10001_biblio_info_7":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-12-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageStart":"6169","bibliographicVolumeNumber":"11","bibliographic_titles":[{},{"bibliographic_title":"Nature Communications","bibliographic_titleLang":"en"}]}]},"item_10001_creator_3":{"attribute_name":"Author","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ito-Kureha, Taku"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miyao, Takahisa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nishijima, Saori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suzuki, Toru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Koizumi, Shin-ichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Villar-Briones, Alejandro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takahashi, Akinori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Akiyama, Nobuko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Morita, Masahiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Naguro, Isao"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishikawa, Hiroki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ichijo, Hidenori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Akiyama, Taishin"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamamoto, Tadashi"}],"nameIdentifiers":[{}]}]},"item_10001_description_5":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"A repertoire of T cells with diverse antigen receptors is selected in the thymus. However, detailed mechanisms underlying this thymic positive selection are not clear. Here we show that the CCR4-NOT complex limits expression of specific genes through deadenylation of mRNA poly(A) tails, enabling positive selection. Specifically, the CCR4-NOT complex is up-regulated in thymocytes before initiation of positive selection, where in turn, it inhibits up-regulation of pro-apoptotic Bbc3 and Dab2ip. Elimination of the CCR4-NOT complex permits up-regulation of Bbc3 during a later stage of positive selection, inducing thymocyte apoptosis. In addition, CCR4-NOT elimination up-regulates Dab2ip at an early stage of positive selection. Thus, CCR4-NOT might control thymocyte survival during two-distinct stages of positive selection by suppressing expression levels of pro-apoptotic molecules. Taken together, we propose a link between CCR4-NOT-mediated mRNA decay and T cell selection in the thymus.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Nature Research"}]},"item_10001_relation_13":{"attribute_name":"PubMedNo.","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:pmid/33268794","subitem_relation_type_select":"PMID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1038/s41467-020-19975-4","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_17":{"attribute_name":"Related site","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.nature.com/articles/s41467-020-19975-4","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"© 2020 The Author(s)."}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2041-1723","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"Author's flag","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-03-17"}],"displaytype":"detail","filename":"Ito-Kureha-2020-The CCR4-NOT deadenylase compl.pdf","filesize":[{"value":"2.3 MB"}],"format":"application/pdf","license_note":"Creative Commons Attribution 4.0 International (https://creativecommons.org/licenses/by/4.0/)","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Ito-Kureha-2020-The CCR4-NOT deadenylase compl","url":"https://oist.repo.nii.ac.jp/record/1981/files/Ito-Kureha-2020-The CCR4-NOT deadenylase compl.pdf"},"version_id":"d0a02353-deaf-45d7-806f-833a13c7909e"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The CCR4–NOT deadenylase complex safeguards thymic positive selection by down-regulating aberrant pro-apoptotic gene expression","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The CCR4–NOT deadenylase complex safeguards thymic positive selection by down-regulating aberrant pro-apoptotic gene expression","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"28","path":["33","67","167"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-03-17"},"publish_date":"2021-03-17","publish_status":"0","recid":"1981","relation_version_is_last":true,"title":["The CCR4–NOT deadenylase complex safeguards thymic positive selection by down-regulating aberrant pro-apoptotic gene expression"],"weko_creator_id":"28","weko_shared_id":28},"updated":"2023-06-26T11:39:38.805406+00:00"}