{"created":"2023-06-26T11:01:18.760425+00:00","id":1989,"links":{},"metadata":{"_buckets":{"deposit":"0d7be3f5-d5eb-4878-ac18-b446e4272d2b"},"_deposit":{"created_by":22,"id":"1989","owners":[22],"pid":{"revision_id":0,"type":"depid","value":"1989"},"status":"published"},"_oai":{"id":"oai:oist.repo.nii.ac.jp:00001989","sets":["7:200"]},"author_link":[],"item_10006_creator_3":{"attribute_name":"Author","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hoh, Hong Huat","creatorNameLang":"en"}]}]},"item_10006_date_granted_11":{"attribute_name":"Degree Conferral Date","attribute_value_mlt":[{"subitem_dategranted":"2020-08-31"}]},"item_10006_degree_grantor_9":{"attribute_name":"Degree Conferrral Institution","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"Okinawa Institute of Science and Technology Graduate University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"38005","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"Degree","attribute_value_mlt":[{"subitem_degreename":"Doctor of Philosophy"}]},"item_10006_description_7":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"Cellular and genetic heterogeneity contributes to the complexity of cancer which poses challenges for cancer therapy. For instance, epithelial-to-mesenchymal transition (EMT) is a physiological phenomenon that was adopted to neoplasm to describe the possibility of carcinoma cells in acquiring mesenchymal traits, leading to invasion and metastatic dissemination. These EMT-induced tumor cells acquire cancer stem cells (CSCs) properties and contribute to heterogeneity within a tumor microenvironment. My thesis is set out to tackle the abovementioned phenomenon, with a common goal of investigating the potential of using exogenous biological agents in modifying the cellular phenotypes and processes of cancer. Firstly, I demonstrated the molecular mechanism and the ability of altering the stem cell property of breast cancer cells by downregulating CD44 molecules using exogenous miRNAs. Secondly, I investigated the potential of bioinspired laminin-derived self-assembling peptides to alter the microenvironment and cellular processes including metabolism of cancer cells for anti-metastatic treatment in pancreatic cancer. Both studies utilized comprehensive molecular biology approaches in elucidating the functional changes and mechanisms behind the therapeutic effects of biological agents using relevant cancer cell lines and animal xenotransplantation models. This thesis provides insights into cancer cell plasticity which can be harnessed for cancer therapy.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_10006_dissertation_number_12":{"attribute_name":"Degree Referral Number","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第60号"}]},"item_10006_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15102/1394.00001791","subitem_identifier_reg_type":"JaLC"}]},"item_10006_rights_13":{"attribute_name":"Copyright Information","attribute_value_mlt":[{"subitem_rights":"© 2020 The Author."}]},"item_10006_text_24":{"attribute_name":"Exam Date","attribute_value_mlt":[{"subitem_text_value":"2020-07-30"}]},"item_10006_version_type_18":{"attribute_name":"Version Format","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-03-19"}],"displaytype":"detail","filename":"296.pdf","filesize":[{"value":"53.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Full_Text","objectType":"fulltext","url":"https://oist.repo.nii.ac.jp/record/1989/files/296.pdf"},"version_id":"8a4449dd-6626-43d1-85df-8ca297d3106b"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-03-19"}],"displaytype":"detail","filename":"doc(6).pdf","filesize":[{"value":"42.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Final_Exam_Abstract","objectType":"abstract","url":"https://oist.repo.nii.ac.jp/record/1989/files/doc(6).pdf"},"version_id":"8a2d14db-7ede-4030-94aa-8b84e30a91f6"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"バイオ試薬投与によるがん細胞や微小環境の代謝・形質変化およびその機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"バイオ試薬投与によるがん細胞や微小環境の代謝・形質変化およびその機構の解明","subitem_title_language":"ja"},{"subitem_title":"Study on Alteration of Cellular Phenotypes and Processes in Cancer Using Exogenous Biological Agents","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"22","path":["200"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-03-19"},"publish_date":"2021-03-19","publish_status":"0","recid":"1989","relation_version_is_last":true,"title":["バイオ試薬投与によるがん細胞や微小環境の代謝・形質変化およびその機構の解明"],"weko_creator_id":"22","weko_shared_id":-1},"updated":"2023-08-31T02:53:11.968353+00:00"}