{"created":"2024-04-15T06:04:42.055366+00:00","id":2000454,"links":{},"metadata":{"_buckets":{"deposit":"588dd761-91f6-46c4-80af-780a95859db8"},"_deposit":{"created_by":33,"id":"2000454","owner":"33","owners":[33],"pid":{"revision_id":0,"type":"depid","value":"2000454"},"status":"published"},"_oai":{"id":"oai:oist.repo.nii.ac.jp:02000454","sets":["7:1707111347047"]},"author_link":[],"control_number":"2000454","item_10006_creator_3":{"attribute_name":"著者(英)","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNames":[{"affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Zobnin, Sergey","creatorNameLang":"en"}]}]},"item_10006_date_granted_11":{"attribute_name":"Degree Conferral Date","attribute_value_mlt":[{"subitem_dategranted":"2024-03-31"}]},"item_10006_degree_grantor_9":{"attribute_name":"Degree Conferrral Institution","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"Okinawa Institute of Science and Technology Graduate University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"38005","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"Degree","attribute_value_mlt":[{"subitem_degreename":"Doctor of Philosophy"}]},"item_10006_description_7":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"Animals need to sense their environment and differentiate sensory states to optimize behavior. For example, a force too weak may fail to pull a desired object closer, while too much effort will be unnecessarily exhausting. The prior experience interacting with similar objects can help generate the required action and produce an expectation of the sensory feedback. Combining prior expectation with the actual sensory observation is formalized with Bayes' rule. The neural mechanisms for such probabilistic computations remain unclear but, in mammals, can be attributed to the specific anatomical patterns of the cerebral cortex. In particular, the pathways carrying bottom-up sensory signals mostly terminate in layer 4 and activate pyramidal neurons of the layer 2/3 of the sensory cortex, while the neurons of deeper layers 5 and 6 mostly receive projections from other cortical areas including the motor cortex. Based on this, I hypothesized that the pyramidal neurons of the superficial layers encode sensory evidence while the deeper layer neurons encode prior and posterior estimations. I conducted a series of lever-pulling experiments on mice, where the lever provided a variable tactile feedback. Calcium imaging of the S1 cortical area using a prism lens enabled me to analyze how matches or mismatches between action-dependent prediction and actual sensory inputs are encoded by neurons in superficial and deep layers.\nI have identified functional asymmetry between superficial and deep cortical layers in the context of the probabilistic sensory-motor task. The deep layers were more associated with the prior information about the expected tactile stimulus in terms of the number of task coding neurons and the amount of information per given population size. In comparison with the deep layers, superficial layers were stronger associated with the sensory information about the actual tactile stimulus, but also encoded prior information. This research contributes to the study of the neural mechanisms underlying probabilistic estimation in the cerebral cortex.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"Degree Referral Number","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第141号"}]},"item_10006_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15102/0002000454","subitem_identifier_reg_type":"JaLC"}]},"item_10006_rights_13":{"attribute_name":"Copyright Information","attribute_value_mlt":[{"subitem_rights":"© 2024 The Author."}]},"item_10006_text_24":{"attribute_name":"Exam Date","attribute_value_mlt":[{"subitem_text_value":"2024-01-31"}]},"item_10006_version_type_18":{"attribute_name":"Version Format","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-04-15"}],"filename":"ZobninSergeyFulltext.pdf","filesize":[{"value":"6.7 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://oist.repo.nii.ac.jp/record/2000454/files/ZobninSergeyFulltext.pdf"},"version_id":"be431689-711e-4aaf-8578-a2e40016d78f"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-04-15"}],"filename":"ZobninSergeyExamAbstract.pdf","filesize":[{"value":"48 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://oist.repo.nii.ac.jp/record/2000454/files/ZobninSergeyExamAbstract.pdf"},"version_id":"ebbe91c3-e14e-492f-a911-26988442a274"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Neurophysiology | Calcium imaging | Animal behaviors | Bayesian inference","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"大脳皮質におけるベイズ的感覚運動統合の研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"大脳皮質におけるベイズ的感覚運動統合の研究","subitem_title_language":"ja"},{"subitem_title":"Investigation of the Bayesian Sensory-Motor Integration in the Cerebral Cortex","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"33","path":["1707111347047"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-04-15"},"publish_date":"2024-04-15","publish_status":"0","recid":"2000454","relation_version_is_last":true,"title":["大脳皮質におけるベイズ的感覚運動統合の研究"],"weko_creator_id":"33","weko_shared_id":-1},"updated":"2024-04-15T08:07:53.098530+00:00"}