@article{oai:oist.repo.nii.ac.jp:02000474, author = {Zhao, Hao and Wang, Yu and Chen, Qiang and Liu, Ying and Gao, Yijian and Müllen, Klaus and Li, Shengliang and Narita, Akimitsu}, journal = {Advanced Science}, month = {Mar}, note = {Photoacoustic imaging (PAI)-guided photothermal therapy (PTT) in the second near-infrared (NIR-II, 1000–1700 nm) window has been attracting attention as a promising cancer theranostic platform. Here, it is reported that the π-extended porphyrins fused with one or two nanographene units (NGP-1 and NGP-2) can serve as a new class of NIR-responsive organic agents, displaying absorption extending to ≈1000 and ≈1400 nm in the NIR-I and NIR-II windows, respectively. NGP-1 and NGP-2 are dispersed in water through encapsulation into self-assembled nanoparticles (NPs), achieving high photothermal conversion efficiency of 60% and 69%, respectively, under 808 and 1064 nm laser irradiation. Moreover, the NIR-II-active NGP-2-NPs demonstrated promising photoacoustic responses, along with high photostability and biocompatibility, enabling PAI and efficient NIR-II PTT of cancer in vivo.}, title = {A Nanographene‐Porphyrin Hybrid for Near‐Infrared‐Ii Phototheranostics}, year = {2024} }