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Exocytic plasma membrane flows remodel endoplasmic reticulum–plasma membrane tethering for septin collar assembly
https://oist.repo.nii.ac.jp/records/2000566
https://oist.repo.nii.ac.jp/records/2000566eedba0ee-1132-4a9f-b698-9b0b7b27e16f
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Sugiyama-2024-Exocytic plasma membrane flows r.pdf (11.6 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
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| 公開日 | 2024-07-05 | |||||||||
| タイトル | ||||||||||
| タイトル | Exocytic plasma membrane flows remodel endoplasmic reticulum–plasma membrane tethering for septin collar assembly | |||||||||
| 言語 | en | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| アクセス権 | ||||||||||
| アクセス権 | open access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
| 著者（英） |
Sugiyama, Shinju
× Sugiyama, Shinju
× Kono, Keiko
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| 書誌情報 |
en : Science Advances 巻 10, 号 11, p. eadj1512, 発行日 2024-03-13 |
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| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Endoplasmic reticulum (ER)–plasma membrane (PM) tethering is crucial for the non-vesicular lipid transport between the ER membrane and the PM. However, the PM-associated ER can impede the PM binding of cytoskeletons and other organelles. It is poorly understood how the competition between the ER and cytoskeletons/organelles on the PM is resolved. Here, we show that, upon septin collar assembly, ER-PM tethering proteins are excluded from the yeast bud sites, and the PM-associated ER is locally detached from the PM. Our results suggest that PM flows by polarized exocytosis extrude PM proteins, including ER-PM tethering proteins, from the bud sites. When the reorganization of the ER-PM tethering was inhibited by exocytosis repression, septin localization was restricted to the PM sites poor in ER-PM tethering proteins. This study proposes machinery reconciling ER-septin competition on the PM, providing mechanistic insights into the spatial organization of PM-associated organelles and cytoskeletons. | |||||||||
| 言語 | en | |||||||||
| 出版者 | ||||||||||
| 出版者 | American Association for the Advancement of Science (AAAS) | |||||||||
| ISSN | ||||||||||
| 収録物識別子タイプ | EISSN | |||||||||
| 収録物識別子 | 2375-2548 | |||||||||
| PubMed番号 | ||||||||||
| 関連タイプ | isIdenticalTo | |||||||||
| 識別子タイプ | PMID | |||||||||
| 関連識別子 | 38478607 | |||||||||
| DOI | ||||||||||
| 関連タイプ | isIdenticalTo | |||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | 10.1126/sciadv.adj1512 | |||||||||
| 権利 | ||||||||||
| 権利情報 | © 2024 the Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. | |||||||||
| 権利 | ||||||||||
| 権利情報Resource | https://creativecommons.org/licenses/by-nc/4.0/ | |||||||||
| 権利情報 | Creative Commons Attribution NonCommercial 4.0 International | |||||||||
| 関連サイト | ||||||||||
| 関連タイプ | isIdenticalTo | |||||||||
| 識別子タイプ | URI | |||||||||
| 関連識別子 | https://www.science.org/doi/10.1126/sciadv.adj1512 | |||||||||
| 著者版フラグ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
