WEKO3
Item
Anatomical and Functional Study of the Superior Colliculus Pathway to the Inferior Olive in Mice
https://doi.org/10.15102/0002000861
https://doi.org/10.15102/0002000861e019b2c5-ceb3-4e15-b215-0f4d74d6e835
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DavidDevianaFulltext.pdf (10.1 MB)
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DavidDevianaExamAbstract.pdf (48 KB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||
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| PubDate | 2025-05-15 | |||||||
| Title | ||||||||
| Title | マウスにおける上丘-下オリーブ経路の解剖学的および機能的研究 | |||||||
| Language | ja | |||||||
| Title | ||||||||
| Title | Anatomical and Functional Study of the Superior Colliculus Pathway to the Inferior Olive in Mice | |||||||
| Language | en | |||||||
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| Language | eng | |||||||
| Resource Type | ||||||||
| Resource Type Identifier | http://purl.org/coar/resource_type/c_db06 | |||||||
| Resource Type | doctoral thesis | |||||||
| Identifier Registration | ||||||||
| Identifier Registration | 10.15102/0002000861 | |||||||
| Identifier Registration Type | JaLC | |||||||
| Access Right | ||||||||
| Access Rights | open access | |||||||
| Access Rights URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| Author |
David, Deviana Lidya
× David, Deviana Lidya
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| Abstract | ||||||||
| Description Type | Abstract | |||||||
| Description | The Inferior olive is an important region for motor learning and movement coordination. Its climbing fiber projections to Purkinje neurons drive complex spike activity, a central element in cerebellar function theories. Although the function of the inferior olive has been investigated by the occurrence of complex spikes during motor learning, it remains unclear how its intrinsic properties and activity shape the generation of complex spikes upon receiving sensory stimulation. To investigate how signals from a pre-olivary structure with a well-defined behavioral role affect IO spiking, I focused on an afferent from the midbrain superior colliculus. The superior colliculus is an evolutionarily conserved midbrain region known for its role in mediating orienting-related movements. The SC-IO pathway serves as an excellent model for studying how inferior olive neurons (IO) respond to their inputs. Additionally, this pathway raises the exciting possibility for orienting-related behaviors modulated by learning through the olivo-cerebellar system. In this study, we explore SC projections to the IO using viral tracers, calcium imaging, and optogenetic stimulation. In addition to the established projections to the medial accessory olive (MAO), we uncover SC axonal projections to the ventral principal olive (PO). Our findings reveal that SC axons terminate on both dendritic shafts and spines of IO neurons, potentially influencing the probability of spike and the network synchronization mediated by gap junctions on dendritic spines. To demonstrate the ability of SC axons to drive IO spiking, we performed in vivo calcium imaging and showed that optogenetic activation of SC inputs not only induces spiking, but also modulates the overall synchronization of the IO. This study lays a foundational framework for exploring the behavioral relevance of the SC-IO pathway in mice. |
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| Language | en | |||||||
| Exam Date | ||||||||
| 2025-03-21 | ||||||||
| Degree Conferral Date | ||||||||
| Date Granted | 2025-04-30 | |||||||
| Degree | ||||||||
| Degree Name | Doctor of Philosophy | |||||||
| Degree Referral Number | ||||||||
| Dissertation Number | 甲第186号 | |||||||
| Degree Conferrral Institution | ||||||||
| Degree Grantor Name Identifier Scheme | kakenhi | |||||||
| Degree Grantor Name Identifier | 38005 | |||||||
| Degree Grantor Name | Okinawa Institute of Science and Technology Graduate University | |||||||
| Version Format | ||||||||
| Version Type | VoR | |||||||
| Version Type Resource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| Copyright Information | ||||||||
| Rights | © 2025 The Author. | |||||||
