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Item
Cerebellar Control of Interceptive Motor Behavior in Head-Fixed Mice
https://doi.org/10.15102/0002000889
https://doi.org/10.15102/0002000889077c30d9-258a-4ab2-bf78-ce8494fc5112
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EltabbalMohamedMostafaKamalFulltext.pdf (10.4 MB)
Download is available from 2026/6/1.
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EltabbalMohamedMostafaKamalExamAbstract.pdf (48 KB)
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EltabbalMohamedMostafaKamalSummary.pdf (75 KB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||
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| PubDate | 2025-06-03 | |||||||
| Title | ||||||||
| Title | 頭部固定マウスの遮断運動行動における側方小脳の役割 | |||||||
| Language | ja | |||||||
| Title | ||||||||
| Title | Cerebellar Control of Interceptive Motor Behavior in Head-Fixed Mice | |||||||
| Language | en | |||||||
| Language | ||||||||
| Language | eng | |||||||
| Resource Type | ||||||||
| Resource Type Identifier | http://purl.org/coar/resource_type/c_db06 | |||||||
| Resource Type | doctoral thesis | |||||||
| Identifier Registration | ||||||||
| Identifier Registration | 10.15102/0002000889 | |||||||
| Identifier Registration Type | JaLC | |||||||
| Access Right | ||||||||
| Access Rights | open access | |||||||
| Access Rights URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| Author |
Eltabbal, Mohamed Mostafa Kamal
× Eltabbal, Mohamed Mostafa Kamal
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| Abstract | ||||||||
| Description Type | Abstract | |||||||
| Description | The ability to perform high-precision motor action to intercept a moving object is fundamental to animal motor behavior within a natural environment. Unlike grasping a fixed object, this sensory-motor action requires top-down predictions and bottom-up sensory information to provide online and adaptive movement control. In the first part of my thesis, I introduce a novel behavioral task where head-fixed mice intercept a moving food pellet with their tongue. I describe the hardware, software, and analysis framework developed for this task and details of the 3D kinematics of discrete tongue-reaching movements, which exhibit distinct motor phases akin to limb reaching. I show how mice learn to coordinate their body movements for successful interception and demonstrate the partial dependence of this behavior on visual inputs. In the second part of my thesis, I examine the contribution of lateral cerebellar circuits to our interception sensorimotor behavior using pharmacological inactivation and one-photon calcium imaging of Purkinje cell dendrites in Crus I and II. These experiments demonstrate that lateral cerebellar circuits are required for successful performance in the interception task. Moreover, I find that Crus I and II complex spiking activity encodes different aspects of our task. While Crus I primarily encodes sensory-related signals, Crus II encodes motor-related signals. Additionally, both lobules display opposing learning-related dynamics. Together, the thesis introduces a new behavioral paradigm as a stepping-stone to investigate the neural basis of interception-like behavior in head-fixed mice. I show an interesting division of labor within lateral cerebellar circuits during this dynamic behavior. Moreover, this behavioral paradigm allows for studying discrete, non-rhythmic, precisely timed tongue movements. |
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| Exam Date | ||||||||
| 2025-03-19 | ||||||||
| Degree Conferral Date | ||||||||
| Date Granted | 2025-05-31 | |||||||
| Degree | ||||||||
| Degree Name | Doctor of Philosophy | |||||||
| Degree Referral Number | ||||||||
| Dissertation Number | 甲第192号 | |||||||
| Degree Conferrral Institution | ||||||||
| Degree Grantor Name Identifier Scheme | kakenhi | |||||||
| Degree Grantor Name Identifier | 38005 | |||||||
| Degree Grantor Name | Okinawa Institute of Science and Technology Graduate University | |||||||
| Version Format | ||||||||
| Version Type | VoR | |||||||
| Version Type Resource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| Copyright Information | ||||||||
| Rights | © 2025 The Author. | |||||||
