WEKO3
Item
Probing Stimulus Encoding in the Olfactory Bulb Using Synthetic Olfactory Stimuli
https://doi.org/10.15102/0002000926
https://doi.org/10.15102/00020009261ec1a42c-0a38-4df9-a6da-ecb80d569df0
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FuXiaochenExamAbstract.pdf (48 KB)
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FuXiaochenFulltext.pdf (5.5 MB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||
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| PubDate | 2025-08-04 | |||||||
| Title | ||||||||
| Title | 合成嗅覚刺激による嗅球の神経符号化の解明 | |||||||
| Language | ja | |||||||
| Title | ||||||||
| Title | Probing Stimulus Encoding in the Olfactory Bulb Using Synthetic Olfactory Stimuli | |||||||
| Language | en | |||||||
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| Language | eng | |||||||
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| Resource Type Identifier | http://purl.org/coar/resource_type/c_db06 | |||||||
| Resource Type | doctoral thesis | |||||||
| Identifier Registration | ||||||||
| Identifier Registration | 10.15102/0002000926 | |||||||
| Identifier Registration Type | JaLC | |||||||
| Access Right | ||||||||
| Access Rights | open access | |||||||
| Access Rights URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| Author |
Fu, Xiaochen
× Fu, Xiaochen
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| Abstract | ||||||||
| Description Type | Abstract | |||||||
| Description | Mitral and tufted cells form the main output of the olfactory bulb. I aim to study the stimulus encoding used by the mitral and tufted cells of the olfactory bulb. I explored the encoding strategies. Neurons can encode sensory information through both spike rate and spike timing. However, in mitral and tufted cells, which of these coding schemes actually drives sensory decisions remains unclear. To dissect their respective roles, I used a system that can modulate the firing rate and timing of the stimuli. By optogenetically activating mitral and tufted cells, I generated distinct activity patterns that varied either in spike rate or timing. My behavioral experiments revealed that mice could quickly learn to discriminate spike number differences but did not learn to distinguish spike timing variations in the sniff cycle using our paradigm. Also, mice were able to discriminate between synchronous vs staggered activations of the output neurons, with accuracy influenced by the timing of stimulus presentation relative to the sniff cycle. Together, these results suggest that firing rate and synchrony may be robust features of neural codes for olfactory communication downstream of olfactory bulb. These findings contribute to our understanding of neural coding strategies in the olfactory system. Future directions include further research to determine how these principles relate to downstream decoding mechanisms and how they apply to natural odor processing. |
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| Language | en | |||||||
| Exam Date | ||||||||
| 2025-07-01 | ||||||||
| Degree Conferral Date | ||||||||
| Date Granted | 2025-07-31 | |||||||
| Degree | ||||||||
| Degree Name | Doctor of Philosophy | |||||||
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| Dissertation Number | 甲第199号 | |||||||
| Degree Conferrral Institution | ||||||||
| Degree Grantor Name Identifier Scheme | kakenhi | |||||||
| Degree Grantor Name Identifier | 38005 | |||||||
| Degree Grantor Name | Okinawa Institute of Science and Technology Graduate University | |||||||
| Version Format | ||||||||
| Version Type | VoR | |||||||
| Version Type Resource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| Copyright Information | ||||||||
| Rights | © 2025 The Author. | |||||||
