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Critical Role of YTHDF2 and CCR4-NOT Complex in Pancreatic β-cell Homeostasis
https://doi.org/10.15102/0002000972
https://doi.org/10.15102/0002000972ca739345-e4f9-48eb-83e5-320ee912f4b4
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TaraYukiFulltext.pdf (3.3 MB)
Download is available from 2026/9/3.
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TaraYukiExamAbstract.pdf (68 KB)
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TaraYukiSumarry.pdf (90 KB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||
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| PubDate | 2025-09-10 | |||||||
| Title | ||||||||
| Title | YTHDF2とCCR4-NOT複合体は膵β細胞の恒常性維持に必須である | |||||||
| Language | ja | |||||||
| Title | ||||||||
| Title | Critical Role of YTHDF2 and CCR4-NOT Complex in Pancreatic β-cell Homeostasis | |||||||
| Language | en | |||||||
| Language | ||||||||
| Language | eng | |||||||
| Resource Type | ||||||||
| Resource Type Identifier | http://purl.org/coar/resource_type/c_db06 | |||||||
| Resource Type | doctoral thesis | |||||||
| Identifier Registration | ||||||||
| Identifier Registration | 10.15102/0002000972 | |||||||
| Identifier Registration Type | JaLC | |||||||
| Access Right | ||||||||
| Access Rights | open access | |||||||
| Access Rights URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| Author |
多良 勇輝
× 多良 勇輝
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| Author |
Tara, Yuki
× Tara, Yuki
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| Abstract | ||||||||
| Description Type | Abstract | |||||||
| Description | Pancreatic β-cells synthesize and secrete insulin to maintain blood glucose levels within a normal range. Decreased insulin secretion and β-cell mass, as well as β-cell dedifferentiation, are observed in type 2 diabetes patients. Thus, maintaining β-cell function and identity is important for glucose homeostasis. Recent studies have shown that the N6-methyladenosine (m6A) methylation level in mRNA is reduced in the islets of patients with type 2 diabetes. m6Amethylated mRNAs are recognized by m6A-binding proteins, which play pivotal roles in various aspects of mRNA processing and metabolism. However, the signaling pathways regulating β- cell homeostasis via m6A modification remain incompletely understood. One of the m6Abinding proteins, YTHDF2, promotes mRNA degradation by recruiting the CCR4-NOT deadenylase complex. This study demonstrates that impaired mRNA turnover via YTHDF2 and the CCR4-NOT complex disrupts β-cell homeostasis. These findings suggest that the degradation of mRNAs in pancreatic β-cells is cooperatively regulated by YTHDF2 and the CCR4-NOT complex, ensuring the maintenance of β-cell function and identity. Furthermore, integrative omics analyses revealed specific mRNAs degraded through this pathway. The genes identified in this study may serve as potential therapeutic targets for type 2 diabetes treatment. | |||||||
| Language | en | |||||||
| Exam Date | ||||||||
| 2025-07-16 | ||||||||
| Degree Conferral Date | ||||||||
| Date Granted | 2025-08-31 | |||||||
| Degree | ||||||||
| Degree Name | Doctor of Philosophy | |||||||
| Degree Referral Number | ||||||||
| Dissertation Number | 甲第200号 | |||||||
| Degree Conferrral Institution | ||||||||
| Degree Grantor Name Identifier Scheme | kakenhi | |||||||
| Degree Grantor Name Identifier | 38005 | |||||||
| Degree Grantor Name | Okinawa Institute of Science and Technology Graduate University | |||||||
| Version Format | ||||||||
| Version Type | VoR | |||||||
| Version Type Resource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| Copyright Information | ||||||||
| Rights | © 2025 The Author. | |||||||
