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Effects of Exogenous Testosterone on the Estrous Cycle, Impulsivity, and Dopamine Transmission in Female Rats
https://doi.org/10.15102/0002000982
https://doi.org/10.15102/000200098293ea9ad9-f925-480c-a65e-08e1ad874238
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YamamuraTanomiFulltext.pdf (4.3 MB)
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YamamuraTanomiExamAbstract.pdf (48 KB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||
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| PubDate | 2025-10-07 | |||||||
| Title | ||||||||
| Title | 雌ラットの発情周期、衝動性およびドーパミン伝達に対する外因性テストステロンの影響 | |||||||
| Language | ja | |||||||
| Title | ||||||||
| Title | Effects of Exogenous Testosterone on the Estrous Cycle, Impulsivity, and Dopamine Transmission in Female Rats | |||||||
| Language | en | |||||||
| Language | ||||||||
| Language | eng | |||||||
| Resource Type | ||||||||
| Resource Type Identifier | http://purl.org/coar/resource_type/c_db06 | |||||||
| Resource Type | doctoral thesis | |||||||
| Identifier Registration | ||||||||
| Identifier Registration | 10.15102/0002000982 | |||||||
| Identifier Registration Type | JaLC | |||||||
| Access Right | ||||||||
| Access Rights | open access | |||||||
| Access Rights URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| Author |
山村 頼
× 山村 頼
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| Author |
Yamamura, Tanomi
× Yamamura, Tanomi
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| Abstract | ||||||||
| Description Type | Abstract | |||||||
| Description | This thesis investigates the behavioral and neural effects of exogenous testosterone on choice impulsivity and nucleus accumbens (NAc) dopamine release in female rats. In Experiment 1, we developed and validated a rodent model of testosterone-based transgender gender-affirming hormone therapy (tGAHT) by demonstrating consistent suppression of estrous cycling following testosterone administration, providing evidence of systemic androgenic effects. In Experiment 2, we tested the effects of testosterone and DHT on sensitivity to delay of reinforcement in an operant task, which measures a component of choice impulsivity. Despite prior evidence linking gonadal steroids to impulsivity and anecdotal reports from people undergoing tGAHT, exogenous androgen administration did not significantly alter sensitivity to delay of reinforcement. This suggests that testosterone may not directly modulate this aspect of impulsive choice behavior in individuals with ovaries. Experiment 3 used fast-scan cyclic voltammetry (FSCV) to examine whether acute and chronic testosterone administration alters NAc dopamine dynamics. Chronic administration of testosterone, but not its non-aromatizable metabolite dihydrotestosterone (DHT), modestly suppressed the enhancement of dopamine signal by methylphenidate, suggesting that the observed chronic effect of testosterone was produced via aromatization to estradiol. These findings build on our emerging understanding of gonadal steroid-dopamine interactions beyond the oversimplified dichotomy of normative "sex differences". | |||||||
| Language | en | |||||||
| Exam Date | ||||||||
| 2025-07-03 | ||||||||
| Degree Conferral Date | ||||||||
| Date Granted | 2025-08-31 | |||||||
| Degree | ||||||||
| Degree Name | Doctor of Philosophy | |||||||
| Degree Referral Number | ||||||||
| Dissertation Number | 甲第202号 | |||||||
| Degree Conferrral Institution | ||||||||
| Degree Grantor Name Identifier Scheme | kakenhi | |||||||
| Degree Grantor Name Identifier | 38005 | |||||||
| Degree Grantor Name | Okinawa Institute of Science and Technology Graduate University | |||||||
| Version Format | ||||||||
| Version Type | VoR | |||||||
| Version Type Resource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| Copyright Information | ||||||||
| Rights | © 2025 The Author. | |||||||
