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Persistent Cerebellar Molecular Layer Interneuron Activity Facilitates Anticipatory Tongue Movements in Mice
https://doi.org/10.15102/0002001096
https://doi.org/10.15102/00020010968b35a2bd-9e13-4a2e-8b1e-381cf7039adf
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GaletzkaCedricFulltext.pdf (9 MB)
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GaletzkaCedricExamAbstract.pdf (64 KB)
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GaletzkaCedricSummary.pdf (52 KB)
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| Item type | デフォルトアイテムタイプ（フル）(1) | |||||||
|---|---|---|---|---|---|---|---|---|
| PubDate | 2026-01-30 | |||||||
| Title | ||||||||
| Title | 持続的な小脳分子層介在神経細胞の活動がマウスにおける予測的な舌の動きを促進する | |||||||
| Language | ja | |||||||
| Title | ||||||||
| Title | Persistent Cerebellar Molecular Layer Interneuron Activity Facilitates Anticipatory Tongue Movements in Mice | |||||||
| Language | en | |||||||
| Creator |
Galetzka, Cedric
× Galetzka, Cedric
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| Access Rights | ||||||||
| Access Rights | open access | |||||||
| Access Rights URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| Rights | ||||||||
| Rights | © 2025 The Author. | |||||||
| Rights | ||||||||
| Rights Resource | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||||
| Rights | Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International | |||||||
| Description | ||||||||
| Description Type | Abstract | |||||||
| Description | Precise, anticipatory movements depend on the brain’s ability to generate motor commands in advance of immediate sensory input. Although the cerebellar cortex receives abundant sensory input via the mossy-fiber pathway, the mechanisms by which continuous sensory signals are transformed remain poorly understood. I co-developed a targeted lick-interception task and investigated the role of molecular layer interneurons during motor learning using wide-field Ca2+ imaging in Crus I and II. Mice either adjusted their lick onset timing (anticipatory) or tongue projection speed (reactive), allowing me to study neural dynamics underlying different adaptive behaviors. My results reveal a sensorimotor division in the left cerebellar hemisphere: Crus I Ca2+ activity increases in response to sensory aspects of the task, while Crus II is engaged during orofacial movements, such as licking and chewing. Over the course of learning, molecular layer interneurons in Crus I acquire persistent sensory-related activity in mice that develop anticipatory behavior. Crus I exhibits enhanced activity up to five seconds before movement onset locked to the spatial position of a continuously moving target independent of body movement. In more anticipatory mice, movement onset becomes linked to the dynamics of this persistent activity, whereas less anticipatory mice adjust their movements based on immediate sensory-related input. Moreover, chemogenetic inhibition of Crus I, but not Crus II, impairs behavioral performance and delays lick onset without altering overall lick parameters. My results indicate that anticipatory behavior in dynamic sensorimotor tasks relies on sensory representations encoded by molecular layer interneurons. | |||||||
| Language | en | |||||||
| Resource Type | ||||||||
| Resource Type Identifier | http://purl.org/coar/resource_type/c_db06 | |||||||
| Resource Type | doctoral thesis | |||||||
| Version Type | ||||||||
| Version Type | VoR | |||||||
| Version Type Resource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| Identifier Registration | ||||||||
| Identifier Registration | 10.15102/0002001096 | |||||||
| Identifier Registration Type | JaLC | |||||||
| Dissertation Number | ||||||||
| Dissertation Number | 甲第216号 | |||||||
| Degree Name | ||||||||
| Language | en | |||||||
| Degree Name | Doctor of Philosophy | |||||||
| Date Granted | ||||||||
| Date Granted | 2025-11-30 | |||||||
| Degree Grantor | ||||||||
| Degree Grantor Name Identifier Scheme | kakenhi | |||||||
| Degree Grantor Name Identifier | 38005 | |||||||
| Language | en | |||||||
| Degree Grantor Name | Okinawa Institute of Science and Technology Graduate University | |||||||
