WEKO3
Item
Catalytic Enantioselective Mannich and retro-Mannich Reactions and Combinations of These Reactions to Synthesize α,α-Disubstituted α-Amino Acid Derivatives
https://doi.org/10.15102/0002001104
https://doi.org/10.15102/000200110468112dab-c453-402d-a0df-3c15167848c9
| Name / File | License | Actions |
|---|---|---|
ChenKuan-LinFulltext.pdf (5.2 MB)
Download is available from 2027/2/2.
|
.png)
|
|
|
ChenKuan-LinExamAbstract.pdf (84 KB)
|
|
|
|
ChenKuan-LinSumarry.pdf (1.5 MB)
|
|
| Item type | デフォルトアイテムタイプ（フル）(1) | |||||||
|---|---|---|---|---|---|---|---|---|
| PubDate | 2026-02-10 | |||||||
| Title | ||||||||
| Title | 触媒的エナンチオ選択的マンニッヒ反応､レトロマンニッヒ反応､およびそれらの組合せによる､α,α-二置換α-アミノ酸誘導体の合成 | |||||||
| Language | ja | |||||||
| Title | ||||||||
| Title | Catalytic Enantioselective Mannich and retro-Mannich Reactions and Combinations of These Reactions to Synthesize α,α-Disubstituted α-Amino Acid Derivatives | |||||||
| Language | en | |||||||
| Creator |
Chen, Kuan-Lin
× Chen, Kuan-Lin
|
|||||||
| Access Rights | ||||||||
| Access Rights | open access | |||||||
| Access Rights URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| Rights | ||||||||
| Rights | © 2026 The Author. | |||||||
| Rights | ||||||||
| Rights Resource | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||||
| Rights | Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International | |||||||
| Subject | ||||||||
| Subject Scheme | Other | |||||||
| Subject | synthetic organic chemistry | |||||||
| Description | ||||||||
| Description Type | Abstract | |||||||
| Description | α,α-Disubstituted α-amino acid derivatives are found in biofunctional molecules and their building blocks. Whereas various synthetic strategies to access to amino acids derivatives have been reported, synthesis of highly enantiomerically enriched α,α-disubstituted α-amino acid derivatives is still a challenge. In this thesis study, catalytic enantioselective Mannich reactions of ketones with cyclic ketimino esters and kinetic resolutions of the racemic versions of Mannich reaction products via retro-Mannich reactions have been developed to afford α,α-disubstituted α-amino acid derivatives. Further, a strategy that combines the Mannich reaction and the retro-Mannich reaction and a strategy that combines the kinetic resolution with the retro-Mannich reaction have been developed to afford α,α-disubstitutedα-amino acid derivatives with very high enantiopurities (er > 99:1). | |||||||
| Language | en | |||||||
| Resource Type | ||||||||
| Resource Type Identifier | http://purl.org/coar/resource_type/c_db06 | |||||||
| Resource Type | doctoral thesis | |||||||
| Version Type | ||||||||
| Version Type | VoR | |||||||
| Version Type Resource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| Identifier Registration | ||||||||
| Identifier Registration | 10.15102/0002001104 | |||||||
| Identifier Registration Type | JaLC | |||||||
| Dissertation Number | ||||||||
| Dissertation Number | 甲第225号 | |||||||
| Degree Name | ||||||||
| Language | en | |||||||
| Degree Name | Doctor of Philosophy | |||||||
| Date Granted | ||||||||
| Date Granted | 2026-01-31 | |||||||
| Degree Grantor | ||||||||
| Degree Grantor Name Identifier Scheme | kakenhi | |||||||
| Degree Grantor Name Identifier | 38005 | |||||||
| Language | en | |||||||
| Degree Grantor Name | Okinawa Institute of Science and Technology Graduate University | |||||||
