{"created":"2023-06-26T11:01:24.606239+00:00","id":2108,"links":{},"metadata":{"_buckets":{"deposit":"f5749404-95c7-47f6-a242-c41836a8f704"},"_deposit":{"created_by":30,"id":"2108","owners":[30],"pid":{"revision_id":0,"type":"depid","value":"2108"},"status":"published"},"_oai":{"id":"oai:oist.repo.nii.ac.jp:00002108","sets":["6:213"]},"author_link":["13889","13887","13893","13890","13886","13894","13885","13897","13884","13892","13895","13888","13896","13898","13891"],"item_10001_biblio_info_7":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-02-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageStart":"1559325820982166","bibliographicVolumeNumber":"19","bibliographic_titles":[{},{"bibliographic_title":"Dose-Response","bibliographic_titleLang":"en"}]}]},"item_10001_creator_3":{"attribute_name":"Author","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Wang, Bing"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tanaka, Kaoru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Katsube, Takanori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Maruyama, Kouichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ninomiya, Yasuharu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Varès, Guillaume"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Liu, Cuihua"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hirakawa, Hirokazu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Murakami, Masahiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fardous, Zeenath"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sultana, Nahida"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fujita, Kazuko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fujimori, Akira"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakajima, Tetsuo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nenoi, Mitsuru"}],"nameIdentifiers":[{}]}]},"item_10001_description_5":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"Radioadaptive response (RAR) describes a phenomenon in a variety of in vitro and in vivo systems that a low-dose of priming ionizing radiation (IR) reduces detrimental effects of a subsequent challenge IR at higher doses. Among in vivo investigations, studies using the mouse RAR model (Yonezawa Effect) showed that RAR could significantly extenuate high-dose IR-induced detrimental effects such as decrease of hematopoietic stem cells and progenitor cells, acute radiation hematopoietic syndrome, genotoxicity and genomic instability. Meanwhile, it has been demonstrated that diet intervention has a great impact on health, and dietary restriction shows beneficial effects on numerous diseases in animal models. In this work, by using the mouse RAR model and mild dietary restriction (MDR), we confirmed that combination of RAR and MDR could more efficiently reduce radiogenotoxic damage without significant change of the RAR phenotype. These findings suggested that MDR may share some common pathways with RAR to activate mechanisms consequently resulting in suppression of genotoxicity. As MDR could also increase resistance to chemotherapy and radiotherapy in normal cells, we propose that combination of MDR, RAR, and other cancer treatments (i.e., chemotherapy and radiotherapy) represent a potential strategy to increase the treatment efficacy and prevent IR risk in humans.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"SAGE Publications "}]},"item_10001_relation_13":{"attribute_name":"PubMedNo.","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:pmid/33628149","subitem_relation_type_select":"PMID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1177/1559325820982166","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_17":{"attribute_name":"Related site","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://journals.sagepub.com/doi/10.1177/1559325820982166","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"© 2021 The Author(s)."}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1559-3258","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"Author's flag","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-05-19"}],"displaytype":"detail","filename":"Wang-2021-Reduced High-Dose Radiation-Induced.pdf","filesize":[{"value":"302.4 kB"}],"format":"application/pdf","license_note":"Creative Commons Attribution-NonCommercial 4.0 International(https://creativecommons.org/licenses/by-nc/4.0/)","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Wang-2021-Reduced High-Dose Radiation-Induced","url":"https://oist.repo.nii.ac.jp/record/2108/files/Wang-2021-Reduced High-Dose Radiation-Induced.pdf"},"version_id":"2ae59e3c-c3c2-4373-a7ec-7f592dc197fc"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"adaptive response","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"dietary restriction","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"radiogenotoxicity","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ionizing radiation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"mice","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Reduced High-Dose Radiation-Induced Residual Genotoxic Damage by Induction of Radioadaptive Response and Prophylactic Mild Dietary Restriction in Mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Reduced High-Dose Radiation-Induced Residual Genotoxic Damage by Induction of Radioadaptive Response and Prophylactic Mild Dietary Restriction in Mice","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"30","path":["213"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-05-19"},"publish_date":"2021-05-19","publish_status":"0","recid":"2108","relation_version_is_last":true,"title":["Reduced High-Dose Radiation-Induced Residual Genotoxic Damage by Induction of Radioadaptive Response and Prophylactic Mild Dietary Restriction in Mice"],"weko_creator_id":"30","weko_shared_id":30},"updated":"2023-06-26T11:37:08.923581+00:00"}