{"created":"2023-06-26T11:01:28.873192+00:00","id":2205,"links":{},"metadata":{"_buckets":{"deposit":"b63684f9-6715-4909-a589-6a4bc7e33717"},"_deposit":{"created_by":30,"id":"2205","owners":[30],"pid":{"revision_id":0,"type":"depid","value":"2205"},"status":"published"},"_oai":{"id":"oai:oist.repo.nii.ac.jp:00002205","sets":["6:213"]},"author_link":["14475","14472","14478","14474","14477","14473","14476"],"item_10001_biblio_info_7":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-06-29","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"13","bibliographicPageStart":"109290","bibliographicVolumeNumber":"35","bibliographic_titles":[{},{"bibliographic_title":"Cell Reports","bibliographic_titleLang":"en"}]}]},"item_10001_creator_3":{"attribute_name":"Author","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ou, Min-Yi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Xiao, Qi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ju, Xiang-Chun"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Zeng, Peng-Ming"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Huang, Jing"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sheng, Ai-Li"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Luo, Zhen-Ge"}],"nameIdentifiers":[{}]}]},"item_10001_description_5":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"Fusion transcripts or RNAs have been found in both disordered and healthy human tissues and cells; however, their physiological functions in the brain development remain unknown. In the analysis of deposited RNA-sequence libraries covering early to middle embryonic stages, we identify 1,055 fusion transcripts present in the developing neocortex. Interestingly, 98 fusion transcripts exhibit distinct expression patterns in various neural progenitors (NPs) or neurons. We focus on CTNNBIP1-CLSTN1 (CTCL), which is enriched in outer radial glial cells that contribute to cortex expansion during human evolution. Intriguingly, downregulation of CTCL in cultured human cerebral organoids causes marked reduction in NPs and precocious neuronal differentiation, leading to impairment of organoid growth. Furthermore, the expression of CTCL fine-tunes Wnt/β-catenin signaling that controls cortex patterning. Together, this work provides evidence indicating important roles of fusion transcript in human brain development and evolution.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Cell Press "}]},"item_10001_relation_13":{"attribute_name":"PubMedNo.","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:pmid/34192541","subitem_relation_type_select":"PMID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1016/j.celrep.2021.109290","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_17":{"attribute_name":"Related site","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.sciencedirect.com/science/article/pii/S2211124721006616?via%3Dihub","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"© 2021 The Authors."}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2211-1247","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"Author's flag","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-08-25"}],"displaytype":"detail","filename":"1-s2.0-S2211124721006616-main.pdf","filesize":[{"value":"4.3 MB"}],"format":"application/pdf","license_note":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (https://creativecommons.org/licenses/by-nc-nd/4.0/)","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"1-s2.0-S2211124721006616-main","url":"https://oist.repo.nii.ac.jp/record/2205/files/1-s2.0-S2211124721006616-main.pdf"},"version_id":"0bf3487d-89bb-48ec-86e3-6c88da67145e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"fusion transcript","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"CTNNBIP1-CLSTN1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cortical expansion","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"basal neural progenitor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"outer radial glia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"neurogenesis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Wnt/β-catenin signaling","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The CTNNBIP1-CLSTN1 fusion transcript regulates human neocortical development","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The CTNNBIP1-CLSTN1 fusion transcript regulates human neocortical development","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"30","path":["213"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-08-25"},"publish_date":"2021-08-25","publish_status":"0","recid":"2205","relation_version_is_last":true,"title":["The CTNNBIP1-CLSTN1 fusion transcript regulates human neocortical development"],"weko_creator_id":"30","weko_shared_id":30},"updated":"2023-06-26T11:24:02.348590+00:00"}