{"created":"2023-06-26T11:01:31.763260+00:00","id":2253,"links":{},"metadata":{"_buckets":{"deposit":"0610cbb5-ca0d-4104-8cf8-e3cb726bdf87"},"_deposit":{"created_by":31,"id":"2253","owners":[31],"pid":{"revision_id":0,"type":"depid","value":"2253"},"status":"published"},"_oai":{"id":"oai:oist.repo.nii.ac.jp:00002253","sets":["6:67"]},"author_link":["14768","14769"],"item_10001_biblio_info_7":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-07-19","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"715675","bibliographicVolumeNumber":"12","bibliographic_titles":[{},{"bibliographic_title":"Frontiers in Immunology","bibliographic_titleLang":"en"}]}]},"item_10001_creator_3":{"attribute_name":"Author","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Akiyama, Taishin"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamamoto, Tadashi"}],"nameIdentifiers":[{}]}]},"item_10001_description_5":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"Development of lymphocytes is precisely regulated by various mechanisms. In addition to transcriptional rates, post-transcriptional regulation of mRNA abundance contributes to differentiation of lymphocytes. mRNA decay is a post-transcriptional mechanism controlling mRNA abundance. The carbon catabolite repression 4 (CCR4)-negative on TATA-less (NOT) complex controls mRNA longevity by catalyzing mRNA deadenylation, which is the rate-limiting step in the mRNA decay pathway. mRNA decay, regulated by the CCR4-NOT complex, is required for differentiation of pro-B to pre-B cells and V(D)J recombination in pro-B cells. In this process, it is likely that the RNA-binding proteins, ZFP36 ring finger protein like 1 and 2, recruit the CCR4-NOT complex to specific target mRNAs, thereby inducing cell quiescence of pro-B cells. A recent study showed that the CCR4-NOT complex participates in positive selection of thymocytes. Mechanistically, the CCR4-NOT deadenylase complex inhibits abnormal apoptosis by reducing the expression level of mRNAs encoding pro-apoptotic proteins, which are otherwise up-regulated during positive selection. We discuss mechanisms regulating CCR4-NOT complex-dependent mRNA decay in lymphocyte development and selection.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Frontiers Media"}]},"item_10001_relation_13":{"attribute_name":"PubMedNo.","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:pmid/34349771","subitem_relation_type_select":"PMID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.3389/fimmu.2021.715675","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_17":{"attribute_name":"Related site","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.frontiersin.org/articles/10.3389/fimmu.2021.715675/full","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"© 2021 Akiyama and Yamamoto."}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1664-3224","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"Author's flag","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-09-09"}],"displaytype":"detail","filename":"Akiyama-fimmu-12-715675 (1).pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","license_note":"CC BY 4.0\nCreative Commons Attribution 4.0 International (https://creativecommons.org/licenses/by/4.0/)","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Akiyama-fimmu-12-715675 (1)","url":"https://oist.repo.nii.ac.jp/record/2253/files/Akiyama-fimmu-12-715675 (1).pdf"},"version_id":"d9795805-045e-46b3-9fa8-79066f034f40"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"mRNA decay","subitem_subject_scheme":"Other"},{"subitem_subject":"CCR4-NOT complex","subitem_subject_scheme":"Other"},{"subitem_subject":"lymphocyte development","subitem_subject_scheme":"Other"},{"subitem_subject":"Apoptosis","subitem_subject_scheme":"Other"},{"subitem_subject":"VDJ recombination","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Regulation of Early Lymphocyte Development via mRNA Decay Catalyzed by the CCR4-NOT Complex","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Regulation of Early Lymphocyte Development via mRNA Decay Catalyzed by the CCR4-NOT Complex","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"31","path":["67"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-09-09"},"publish_date":"2021-09-09","publish_status":"0","recid":"2253","relation_version_is_last":true,"title":["Regulation of Early Lymphocyte Development via mRNA Decay Catalyzed by the CCR4-NOT Complex"],"weko_creator_id":"31","weko_shared_id":31},"updated":"2023-06-26T11:34:07.825966+00:00"}