@article{oai:oist.repo.nii.ac.jp:00000229,
 author = {Peigné, Cassie-Marie and Léger, Alexandra and Gesnel, Marie-Claude and Konczak, Fabienne and Olive, Daniel and Bonneville, Marc and Breathnach, Richard and Scotet, Emmanuel},
 issue = {11},
 journal = {The Journal of Immunology},
 month = {May},
 note = {Vγ9Vδ2 T lymphocytes are the major human peripheral γδ T cell subset, with broad reactivity against stressed human cells, including tumor cells. Vγ9Vδ2 T cells are specifically activated by small phosphorylated metabolites called phosphoantigens (PAg). Stress-induced changes in target cell PAg levels are specifically detected by butyrophilin (BTN)3A1, using its intracellular B30.2 domain. This leads to the activation of Vγ9Vδ2 T cells. In this study, we show that changes in the juxtamembrane domain of BTN3A1, but not its transmembrane domain, induce a markedly enhanced or reduced γδ T cell reactivity. There is thus a specific requirement for BTN3A1’s juxtamembrane domain for correct γδ T cell–related function. This work identified, as being of particular importance, a juxtamembrane domain region of BTN3A molecules identified as a possible dimerization interface and that is located close to the start of the B30.2 domain.},
 pages = {4228--4234},
 title = {The Juxtamembrane Domain of Butyrophilin BTN3A1 Controls Phosphoantigen-Mediated Activation of Human Vγ9Vδ2 T Cells},
 volume = {198},
 year = {2017}
}