{"created":"2023-06-26T11:00:03.444910+00:00","id":229,"links":{},"metadata":{"_buckets":{"deposit":"64f1b348-beb4-4ae4-ba07-b08d092f55bd"},"_deposit":{"created_by":27,"id":"229","owners":[27],"pid":{"revision_id":0,"type":"depid","value":"229"},"status":"published"},"_oai":{"id":"oai:oist.repo.nii.ac.jp:00000229","sets":["6:57"]},"author_link":["1476","1478","1475","1479","1473","1472","1474","1477"],"item_10001_biblio_info_7":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-05-22","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageEnd":"4234","bibliographicPageStart":"4228","bibliographicVolumeNumber":"198","bibliographic_titles":[{},{"bibliographic_title":"The Journal of Immunology","bibliographic_titleLang":"en"}]}]},"item_10001_creator_3":{"attribute_name":"Author","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Peigné, Cassie-Marie"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Léger, Alexandra"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Gesnel, Marie-Claude"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Konczak, Fabienne"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Olive, Daniel"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Bonneville, Marc"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Breathnach, Richard"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Scotet, Emmanuel"}],"nameIdentifiers":[{}]}]},"item_10001_description_5":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"Vγ9Vδ2 T lymphocytes are the major human peripheral γδ T cell subset, with broad reactivity against stressed human cells, including tumor cells. Vγ9Vδ2 T cells are specifically activated by small phosphorylated metabolites called phosphoantigens (PAg). Stress-induced changes in target cell PAg levels are specifically detected by butyrophilin (BTN)3A1, using its intracellular B30.2 domain. This leads to the activation of Vγ9Vδ2 T cells. In this study, we show that changes in the juxtamembrane domain of BTN3A1, but not its transmembrane domain, induce a markedly enhanced or reduced γδ T cell reactivity. There is thus a specific requirement for BTN3A1’s juxtamembrane domain for correct γδ T cell–related function. This work identified, as being of particular importance, a juxtamembrane domain region of BTN3A molecules identified as a possible dimerization interface and that is located close to the start of the B30.2 domain.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"The American Association of Immunologists, Inc."}]},"item_10001_relation_13":{"attribute_name":"PubMedNo.","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"info:pmid/28461569","subitem_relation_type_select":"PMID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.4049/jimmunol.1601910","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_17":{"attribute_name":"Related site","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.jimmunol.org/content/198/11/4228","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"© 2017 The American Association of Immunologists, Inc."}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0022-1767","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The Juxtamembrane Domain of Butyrophilin BTN3A1 Controls Phosphoantigen-Mediated Activation of Human Vγ9Vδ2 T Cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The Juxtamembrane Domain of Butyrophilin BTN3A1 Controls Phosphoantigen-Mediated Activation of Human Vγ9Vδ2 T Cells","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"27","path":["57"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-05-23"},"publish_date":"2018-05-23","publish_status":"0","recid":"229","relation_version_is_last":true,"title":["The Juxtamembrane Domain of Butyrophilin BTN3A1 Controls Phosphoantigen-Mediated Activation of Human Vγ9Vδ2 T Cells"],"weko_creator_id":"27","weko_shared_id":27},"updated":"2023-06-26T12:08:31.322533+00:00"}