{"created":"2023-06-26T11:01:54.778589+00:00","id":2669,"links":{},"metadata":{"_buckets":{"deposit":"3eafab4c-d249-445b-91dc-9ba7195e5a88"},"_deposit":{"created_by":22,"id":"2669","owners":[22],"pid":{"revision_id":0,"type":"depid","value":"2669"},"status":"published"},"_oai":{"id":"oai:oist.repo.nii.ac.jp:00002669","sets":["7:235"]},"author_link":[],"item_10006_creator_3":{"attribute_name":"Author","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Barua, Agneesh","creatorNameLang":"en"}]}]},"item_10006_date_granted_11":{"attribute_name":"Degree Conferral Date","attribute_value_mlt":[{"subitem_dategranted":"2022-07-01"}]},"item_10006_degree_grantor_9":{"attribute_name":"Degree Conferrral Institution","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"Okinawa Institute of Science and Technology Graduate University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"38005","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"Degree","attribute_value_mlt":[{"subitem_degreename":"Doctor of Philosophy"}]},"item_10006_description_7":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"Venomous animals have fascinated humans for millennia. How nature shaped a simple biological secretion into a potent chemical weapon is a testament to evolution’s power and versatility. However, the early origins and genetic mechanisms of venom evolution are not clearly understood. Venoms consist of proteinaceous cocktails where each protein can be mapped to a specific gene; I utilized this genetic tractability to uncover the molecular and genetic mechanisms behind its evolution. Using a combination of quantitative genetics, transcriptomics, and phylogenetics, I have identified specific mechanisms that led to the origin of oral venoms in mammals and reptiles. Oral venoms originated from an ancient conserved gene regulatory network whose primary role was maintaining cellular homeostasis during increased protein production. This ancient system could tolerate high protein loads, facilitating the parallel recruitment of various diverse protein families into the ancient venom. Venom complexity then increased by sequence and copy number variation of toxins. High copy numbers contributed to this system’s phenotypic flexibility, allowing it to further diversify through changes in evolutionary rates and by altering the combinations of toxins used. These features enabled evolution to refine venom cocktails to form optimal formulations. I provide the first unified and deep evolutionary model describing the early steps in forming a venom system and show how millions of years of evolution produced venom phenotypes in extant lineages. All chapters of this thesis have been peer-reviewed and published.","subitem_description_type":"Other"}]},"item_10006_dissertation_number_12":{"attribute_name":"Degree Referral Number","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第96号"}]},"item_10006_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15102/1394.00002408","subitem_identifier_reg_type":"JaLC"}]},"item_10006_rights_13":{"attribute_name":"Copyright Information","attribute_value_mlt":[{"subitem_rights":"© 2022 The Author."}]},"item_10006_text_24":{"attribute_name":"Exam Date","attribute_value_mlt":[{"subitem_text_value":"2022-06-08"}]},"item_10006_version_type_18":{"attribute_name":"Version Format","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-07-01"}],"displaytype":"detail","filename":"AgneeshBarua - FullText.pdf","filesize":[{"value":"9.1 MB"}],"format":"application/pdf","licensefree":"CC BY-NC-ND 4.0\nCreative Commons Attribution-NonCommercial-NoDerivatives 4.0 International(https://creativecommons.org/licenses/by-nc-nd/4.0/)","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AgneeshBarua - FullText","objectType":"fulltext","url":"https://oist.repo.nii.ac.jp/record/2669/files/AgneeshBarua - FullText.pdf"},"version_id":"1c61b92e-61dc-4069-9896-4e3872166d3c"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-07-01"}],"displaytype":"detail","filename":"AgneeshBarua - FinalExamAbstract.pdf","filesize":[{"value":"42.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AgneeshBarua - FinalExamAbstract","objectType":"abstract","url":"https://oist.repo.nii.ac.jp/record/2669/files/AgneeshBarua - FinalExamAbstract.pdf"},"version_id":"530db234-c589-4387-a106-95e72bbbcf93"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"毒液の進化遺伝学：動物はどのように完璧な化学物資の武器を作るのか","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"毒液の進化遺伝学：動物はどのように完璧な化学物資の武器を作るのか","subitem_title_language":"ja"},{"subitem_title":"The Evolutionary Genetics of Venoms: How Nature Created the Perfect Chemical Weapon","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"22","path":["235"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-07-01"},"publish_date":"2022-07-01","publish_status":"0","recid":"2669","relation_version_is_last":true,"title":["毒液の進化遺伝学：動物はどのように完璧な化学物資の武器を作るのか"],"weko_creator_id":"22","weko_shared_id":-1},"updated":"2023-09-01T02:33:04.042001+00:00"}