{"created":"2023-06-26T11:01:55.308913+00:00","id":2678,"links":{},"metadata":{"_buckets":{"deposit":"d1901f9c-4daa-4ee4-a3f2-4d2eb3f191cd"},"_deposit":{"created_by":30,"id":"2678","owners":[30],"pid":{"revision_id":0,"type":"depid","value":"2678"},"status":"published"},"_oai":{"id":"oai:oist.repo.nii.ac.jp:00002678","sets":["6:68"]},"author_link":["17312","17313","17311","17314","17315","17310","17316"],"item_10001_biblio_info_7":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-03-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageStart":"1296","bibliographicVolumeNumber":"13","bibliographic_titles":[{},{"bibliographic_title":"Nature Communications","bibliographic_titleLang":"en"}]}]},"item_10001_creator_3":{"attribute_name":"Author","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Reynolds, John N. J."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Avvisati, Riccardo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Dodson, Paul D."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fisher, Simon D."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Oswald, Manfred J."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Wickens, Jeffery R."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Zhang, Yan-Feng"}],"nameIdentifiers":[{}]}]},"item_10001_description_5":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"Dopamine-dependent long-term plasticity is believed to be a cellular mechanism underlying reinforcement learning. In response to reward and reward-predicting cues, phasic dopamine activity potentiates the efficacy of corticostriatal synapses on spiny projection neurons (SPNs). Since phasic dopamine activity also encodes other behavioural variables, it is unclear how postsynaptic neurons identify which dopamine event is to induce long-term plasticity. Additionally, it is unknown how phasic dopamine released from arborised axons can potentiate targeted striatal synapses through volume transmission. To examine these questions we manipulated striatal cholinergic interneurons (ChIs) and dopamine neurons independently in two distinct in vivo paradigms. We report that long-term potentiation (LTP) at corticostriatal synapses with SPNs is dependent on the coincidence of pauses in ChIs and phasic dopamine activation, critically accompanied by SPN depolarisation. Thus, the ChI pause defines the time window for phasic dopamine to induce plasticity, while depolarisation of SPNs constrains the synapses eligible for plasticity.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Nature Portfolio"}]},"item_10001_relation_13":{"attribute_name":"PubMedNo.","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:pmid/35277506","subitem_relation_type_select":"PMID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1038/s41467-022-28950-0","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_17":{"attribute_name":"Related site","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.nature.com/articles/s41467-022-28950-0","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"© 2022 The Author(s)."}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2041-1723","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"Author's flag","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-07-05"}],"displaytype":"detail","filename":"s41467-022-28950-0.pdf","filesize":[{"value":"1.6 MB"}],"format":"application/pdf","license_note":"Creative Commons Attribution 4.0 International(https://creativecommons.org/licenses/by/4.0/)","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"s41467-022-28950-0","url":"https://oist.repo.nii.ac.jp/record/2678/files/s41467-022-28950-0.pdf"},"version_id":"9ea1ec32-29ff-481b-bb54-6a2f6fbe6a30"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Coincidence of cholinergic pauses, dopaminergic activation and depolarisation of spiny projection neurons drives synaptic plasticity in the striatum","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Coincidence of cholinergic pauses, dopaminergic activation and depolarisation of spiny projection neurons drives synaptic plasticity in the striatum","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"30","path":["68"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-07-05"},"publish_date":"2022-07-05","publish_status":"0","recid":"2678","relation_version_is_last":true,"title":["Coincidence of cholinergic pauses, dopaminergic activation and depolarisation of spiny projection neurons drives synaptic plasticity in the striatum"],"weko_creator_id":"30","weko_shared_id":30},"updated":"2023-06-26T11:26:38.695958+00:00"}