{"created":"2023-06-26T11:01:55.375524+00:00","id":2679,"links":{},"metadata":{"_buckets":{"deposit":"fb0987ce-3bb0-4959-9ca1-6737f2f34ceb"},"_deposit":{"created_by":30,"id":"2679","owners":[30],"pid":{"revision_id":0,"type":"depid","value":"2679"},"status":"published"},"_oai":{"id":"oai:oist.repo.nii.ac.jp:00002679","sets":["6:68"]},"author_link":["17318","17320","17319","17317","17321"],"item_10001_biblio_info_7":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-09-15","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"37","bibliographicPageEnd":"7847","bibliographicPageStart":"7831","bibliographicVolumeNumber":"41","bibliographic_titles":[{},{"bibliographic_title":"The Journal of Neuroscience","bibliographic_titleLang":"en"}]}]},"item_10001_creator_3":{"attribute_name":"Author","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Pommer, Stefan"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Akamine, Yumiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Schiffmann, Serge N."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"de Kerchove d'Exaerde, Alban"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Wickens, Jeffery R."}],"nameIdentifiers":[{}]}]},"item_10001_description_5":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"The principal neurons of the striatum, the spiny projection neurons (SPNs), make inhibitory synaptic connections with each other via collaterals of their main axon, forming a local lateral inhibition network. Serotonin, acting via the 5-HT1B receptor, modulates neurotransmitter release from SPN terminals in striatal output nuclei, but the role of 5-HT1B receptors in lateral inhibition among SPNs in the striatum is unknown. Here, we report the effects of 5-HT1B receptor activation on lateral inhibition in the mouse striatum. Whole-cell recordings were made from SPNs in acute brain slices of either sex, while optogenetically activating presynaptic SPNs or fast-spiking interneurons (FSIs). Activation of 5-HT1B receptors significantly reduced the amplitude of IPSCs evoked by optical stimulation of both direct and indirect pathway SPNs. This reduction was blocked by application of a 5-HT1B receptor antagonist. Activation of 5-HT1B receptors did not reduce the amplitude of IPSCs evoked from FSIs. These results suggest a new role for serotonin as a modulator of lateral inhibition among striatal SPNs. The 5-HT1B receptor may, therefore, be a suitable target for future behavioral experiments investigating the currently unknown role of lateral inhibition in the function of the striatum.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Society for Neuroscience"}]},"item_10001_relation_13":{"attribute_name":"PubMedNo.","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:pmid/34348999","subitem_relation_type_select":"PMID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1523/JNEUROSCI.1037-20.2021","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_17":{"attribute_name":"Related site","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.jneurosci.org/content/41/37/7831","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"© 2021 Pommer et al."}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1529-2401","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"0270-6474","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"Author's flag","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-07-05"}],"displaytype":"detail","filename":"7831.full.pdf","filesize":[{"value":"6.1 MB"}],"format":"application/pdf","license_note":"Creative Commons Attribution 4.0 International(https://creativecommons.org/licenses/by/4.0/)","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"7831.full","url":"https://oist.repo.nii.ac.jp/record/2679/files/7831.full.pdf"},"version_id":"69cc7a56-d5f8-4ab9-9e55-b117118d4a6f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"GABA","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"lateral inhibition","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"MSN","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"serotonin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"SPN","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"synapse","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The Effect of Serotonin Receptor 5-HT1B on Lateral Inhibition between Spiny Projection Neurons in the Mouse Striatum","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The Effect of Serotonin Receptor 5-HT1B on Lateral Inhibition between Spiny Projection Neurons in the Mouse Striatum","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"30","path":["68"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-07-05"},"publish_date":"2022-07-05","publish_status":"0","recid":"2679","relation_version_is_last":true,"title":["The Effect of Serotonin Receptor 5-HT1B on Lateral Inhibition between Spiny Projection Neurons in the Mouse Striatum"],"weko_creator_id":"30","weko_shared_id":30},"updated":"2023-06-26T11:26:37.499927+00:00"}