{"created":"2023-06-26T11:01:57.520638+00:00","id":2717,"links":{},"metadata":{"_buckets":{"deposit":"1827cc95-72ed-498e-a05f-004b1ffde748"},"_deposit":{"created_by":31,"id":"2717","owners":[31],"pid":{"revision_id":0,"type":"depid","value":"2717"},"status":"published"},"_oai":{"id":"oai:oist.repo.nii.ac.jp:00002717","sets":["6:74"]},"author_link":["17523","17522","17521","17524"],"item_10001_biblio_info_7":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-06-22","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageStart":"e4362","bibliographicVolumeNumber":"31","bibliographic_titles":[{},{"bibliographic_title":"Protein Science","bibliographic_titleLang":"en"}]}]},"item_10001_creator_3":{"attribute_name":"Author","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Jayaraman, Vijay"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Toledo‐Patiño, Saacnicteh"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Noda‐García, Lianet"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Laurino, Paola"}],"nameIdentifiers":[{}]}]},"item_10001_description_5":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"How do proteins evolve? How do changes in sequence mediate changes in protein structure, and in turn in function? This question has multiple angles, ranging from biochemistry and biophysics to evolutionary biology. This review provides a brief integrated view of some key mechanistic aspects of protein evolution. First, we explain how protein evolution is primarily driven by randomly acquired genetic mutations and selection for function, and how these mutations can even give rise to completely new folds. Then, we also comment on how phenotypic protein variability, including promiscuity, transcriptional and translational errors, may also accelerate this process, possibly via “plasticity-first” mechanisms. Finally, we highlight open questions in the field of protein evolution, with respect to the emergence of more sophisticated protein systems such as protein complexes, pathways, and the emergence of pre-LUCA enzymes.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"John Wiley & Sons, Inc."}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1002/pro.4362","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_17":{"attribute_name":"Related site","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://onlinelibrary.wiley.com/doi/10.1002/pro.4362","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"© 2022 The Author(s)"},{"subitem_rights":"This is the peer reviewed version of the following article: ayaraman, V, Toledo-Patiño, S, Noda-García, L, Laurino, P. Mechanisms of protein evolution. Protein Science. 2022; 31( 7):e4362. https://doi.org/10.1002/pro.4362, which has been published in final form at https://onlinelibrary.wiley.com/doi/10.1002/pro.4362. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited."}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0961-8368","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"1469-896X","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"Author's flag","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-06-22"}],"displaytype":"detail","filename":"20220511_Mechanisms of protein evolution_clea.pdf","filesize":[{"value":"1.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"20220511_Mechanisms of protein evolution_clea","url":"https://oist.repo.nii.ac.jp/record/2717/files/20220511_Mechanisms of protein evolution_clea.pdf"},"version_id":"7d9917b3-3f52-4aad-96f4-c01203983cb7"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Mechanisms of protein evolution","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Mechanisms of protein evolution","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"31","path":["74"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-07-27"},"publish_date":"2022-07-27","publish_status":"0","recid":"2717","relation_version_is_last":true,"title":["Mechanisms of protein evolution"],"weko_creator_id":"31","weko_shared_id":31},"updated":"2023-06-26T11:25:54.262294+00:00"}