@article{oai:oist.repo.nii.ac.jp:00002777,
 author = {Hu, Xunwu and Roy, Sona Rani and Jin, Chengzhi and Li, Guanying and Zhang, Qizheng and Asano, Natsuko and Asahina, Shunsuke and Kajiwara, Tomoko and Takahara, Atsushi and Feng, Bolu and Aoki, Kazuhiro and Xu, Chenjie and Zhang, Ye},
 issue = {1},
 journal = {Nature Communications},
 month = {Aug},
 note = {Advances in mechanistic understanding of integrin-mediated adhesion highlight the importance of precise control of ligand presentation in directing cell migration. Top-down nanopatterning limited the spatial presentation to sub-micron placing restrictions on both fundamental study and biomedical applications. To break the constraint, here we propose a bottom-up nanofabrication strategy to enhance the spatial resolution to the molecular level using simple formulation that is applicable as treatment agent. Via self-assembly and co-assembly, precise control of ligand presentation is succeeded by varying the proportions of assembling ligand and nonfunctional peptide. Assembled nanofilaments fulfill multi-functions exerting enhancement to suppression effect on cell migration with tunable amplitudes. Self-assembled nanofilaments possessing by far the highest ligand density prevent integrin/actin disassembly at cell rear, which expands the perspective of ligand-density-dependent-modulation, revealing valuable inputs to therapeutic innovations in tumor metastasis.},
 title = {Control cell migration by engineering integrin ligand assembly},
 volume = {13},
 year = {2022}
}