{"created":"2023-06-26T11:02:00.835671+00:00","id":2777,"links":{},"metadata":{"_buckets":{"deposit":"860bc637-a095-465e-9c26-c27aee0a3774"},"_deposit":{"created_by":31,"id":"2777","owners":[31],"pid":{"revision_id":0,"type":"depid","value":"2777"},"status":"published"},"_oai":{"id":"oai:oist.repo.nii.ac.jp:00002777","sets":["6:63"]},"author_link":["17873","17877","17878","17883","17872","17874","17876","17880","17881","17882","17884","17875","17879"],"item_10001_biblio_info_7":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-08-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageStart":"5002","bibliographicVolumeNumber":"13","bibliographic_titles":[{},{"bibliographic_title":"Nature Communications","bibliographic_titleLang":"en"}]}]},"item_10001_creator_3":{"attribute_name":"Author","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hu, Xunwu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Roy, Sona Rani"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Jin, Chengzhi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Li, Guanying"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Zhang, Qizheng"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Asano, Natsuko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Asahina, Shunsuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kajiwara, Tomoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takahara, Atsushi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Feng, Bolu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Aoki, Kazuhiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Xu, Chenjie"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Zhang, Ye"}],"nameIdentifiers":[{}]}]},"item_10001_description_5":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"Advances in mechanistic understanding of integrin-mediated adhesion highlight the importance of precise control of ligand presentation in directing cell migration. Top-down nanopatterning limited the spatial presentation to sub-micron placing restrictions on both fundamental study and biomedical applications. To break the constraint, here we propose a bottom-up nanofabrication strategy to enhance the spatial resolution to the molecular level using simple formulation that is applicable as treatment agent. Via self-assembly and co-assembly, precise control of ligand presentation is succeeded by varying the proportions of assembling ligand and nonfunctional peptide. Assembled nanofilaments fulfill multi-functions exerting enhancement to suppression effect on cell migration with tunable amplitudes. Self-assembled nanofilaments possessing by far the highest ligand density prevent integrin/actin disassembly at cell rear, which expands the perspective of ligand-density-dependent-modulation, revealing valuable inputs to therapeutic innovations in tumor metastasis.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Nature Portfolio"}]},"item_10001_relation_13":{"attribute_name":"PubMedNo.","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:pmid/36008449","subitem_relation_type_select":"PMID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1038/s41467-022-32686-2","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_17":{"attribute_name":"Related site","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.nature.com/articles/s41467-022-32686-2","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"© 2022 The Author(s)"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2041-1723","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"Author's flag","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-09-05"}],"displaytype":"detail","filename":"s41467-022-32686-2 (1).pdf","filesize":[{"value":"15.0 MB"}],"format":"application/pdf","license_note":"CC BY 4.0\nCreative Commons Attribution 4.0 International (https://creativecommons.org/licenses/by/4.0/)","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"s41467-022-32686-2 (1)","url":"https://oist.repo.nii.ac.jp/record/2777/files/s41467-022-32686-2 (1).pdf"},"version_id":"20ca650e-c106-4eb2-9cce-70b7966c19e7"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Control cell migration by engineering integrin ligand assembly","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Control cell migration by engineering integrin ligand assembly","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"31","path":["63"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-09-05"},"publish_date":"2022-09-05","publish_status":"0","recid":"2777","relation_version_is_last":true,"title":["Control cell migration by engineering integrin ligand assembly"],"weko_creator_id":"31","weko_shared_id":31},"updated":"2023-06-26T11:24:23.436136+00:00"}