{"created":"2023-06-26T11:02:01.439531+00:00","id":2788,"links":{},"metadata":{"_buckets":{"deposit":"a9eb82f4-1123-4798-a27f-e2875d6f543e"},"_deposit":{"created_by":31,"id":"2788","owners":[31],"pid":{"revision_id":0,"type":"depid","value":"2788"},"status":"published"},"_oai":{"id":"oai:oist.repo.nii.ac.jp:00002788","sets":["6:191"]},"author_link":["17944","17945","17946","17943","17942"],"item_10001_biblio_info_7":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-09-28","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"2200315","bibliographic_titles":[{},{"bibliographic_title":"Macromolecular Bioscience","bibliographic_titleLang":"en"}]}]},"item_10001_creator_3":{"attribute_name":"Author","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Agrawal, Lokesh"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Vimal, Sunil Kumar"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Barzaghi, Paolo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takashi, Shiga"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Terenzio, Marco"}],"nameIdentifiers":[{}]}]},"item_10001_description_5":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"Due to the severity of peripheral nerve and spinal cord injuries, treatment options for patients are limited. In this context, biomaterials designed to promote regeneration and reinstate the lost function are being explored. Such biomaterials should be able to mimic the biological, chemical, and physical cues of the extracellular matrix for maximum effectiveness as therapeutic agents. Development of biomaterials with desirable physical, chemical, and electrical properties, however, has proven challenging. Here, we propose a novel biomaterial formulation achieved by blending the pigment melanin and the natural polymer Poly (3-hydroxybutyrate). Physio-chemical measurements of electrospun fibers revealed a feature rich surface nano-topography, a semiconducting-nature and brain-tissue-like poroviscoelastic properties. Resulting fibers improved cell adhesion and growth of mouse sensory and motor neurons, without any observable toxicity. Further, the presence of polar functional groups positively affected the kinetics of fibers degradation at a pH (∼7.4) comparable to that of body fluids. Thus, melanin-PHB blended scaffolds were found to be physio-chemically, electrically, and biologically compatible with neural tissues and could be used as a regenerative modality for neural tissue injuries. ","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"John Wiley & Sons, Inc."}]},"item_10001_relation_13":{"attribute_name":"PubMedNo.","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:pmid/36114714","subitem_relation_type_select":"PMID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1002/mabi.202200315","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_17":{"attribute_name":"Related site","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://onlinelibrary.wiley.com/doi/10.1002/mabi.202200315","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"© 2022 Wiley-VCH GmbH"},{"subitem_rights":"This is the peer reviewed version of the following article: Agrawal, L., Vimal, S. K., Barzaghi, P., Takashi, S., Terenzio, M., Biodegradable and electrically conductive melanin-Poly (3-hydroxybutyrate) 3D fibrous scaffolds for neural tissue engineering applications. Macromol. Biosci. 2022, 2200315., which has been published in final form at https://onlinelibrary.wiley.com/doi/10.1002/mabi.202200315. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited."}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1616-5187","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"1616-5195","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"Author's flag","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-09-28"}],"displaytype":"detail","filename":"Agrawal-Biodegradable and electrically conduct.pdf","filesize":[{"value":"4.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Agrawal-Biodegradable and electrically conduct","url":"https://oist.repo.nii.ac.jp/record/2788/files/Agrawal-Biodegradable and electrically conduct.pdf"},"version_id":"96a0d41a-38a7-4654-8592-2faefef5cdf7"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Electrospinning","subitem_subject_scheme":"Other"},{"subitem_subject":"fibrous scaffolds","subitem_subject_scheme":"Other"},{"subitem_subject":"electroconductive","subitem_subject_scheme":"Other"},{"subitem_subject":"biodegradable","subitem_subject_scheme":"Other"},{"subitem_subject":"melanin","subitem_subject_scheme":"Other"},{"subitem_subject":"Poly (3hydroxybutyrate)","subitem_subject_scheme":"Other"},{"subitem_subject":"neural tissue engineering","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Biodegradable and electrically conductive melanin‐Poly (3‐hydroxybutyrate) 3D fibrous scaffolds for neural tissue engineering applications","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Biodegradable and electrically conductive melanin‐Poly (3‐hydroxybutyrate) 3D fibrous scaffolds for neural tissue engineering applications","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"31","path":["191"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-09-21"},"publish_date":"2022-09-21","publish_status":"0","recid":"2788","relation_version_is_last":true,"title":["Biodegradable and electrically conductive melanin‐Poly (3‐hydroxybutyrate) 3D fibrous scaffolds for neural tissue engineering applications"],"weko_creator_id":"31","weko_shared_id":31},"updated":"2023-06-26T11:24:03.486983+00:00"}