@article{oai:oist.repo.nii.ac.jp:00002817,
 author = {Zhao, Hao and Xu, Xiushang and Zhou, Long and Hu, Yunbin and Huang, Yiming and Narita, Akimitsu},
 issue = {1},
 journal = {Small},
 month = {Nov},
 note = {Helicene-based therapeutic agents for organelle-targeted photodynamic therapy (PDT) involving both type I and II are challenging and still underexplored. Herein, water-soluble nanoparticles containing twisted double [7]carbohelicene (D7H-NPs) are prepared through self-assembly with 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] by a nanoprecipitation method. D7H-NPs display high water solubility with an average size of 46 ± 2 nm. Notably, D7H-NPs can generate efficient singlet oxygen (1O2) and superoxide anion (O2· −) upon white light irradiation, forming the basis of PDT. Moreover, the typical accumulation in lysosomes of 4T1 cancer cells paves the way to use D7H-NPs for lysosome-targeted cancer phototherapeutics. This paper reports a promising helicene-based phototherapeutic agent involving both type I and II PDT for organelle-targeted biotherapy.},
 title = {Water‐Soluble Nanoparticles with Twisted Double [7]Carbohelicene for Lysosome‐Targeted Cancer Photodynamic Therapy},
 volume = {18},
 year = {2021}
}