{"created":"2023-06-26T11:02:02.829176+00:00","id":2817,"links":{},"metadata":{"_buckets":{"deposit":"61a0ba49-2b94-45d6-a9ed-f85d59bc72dc"},"_deposit":{"created_by":31,"id":"2817","owners":[31],"pid":{"revision_id":0,"type":"depid","value":"2817"},"status":"published"},"_oai":{"id":"oai:oist.repo.nii.ac.jp:00002817","sets":["6:177"]},"author_link":["18054","18053","18057","18056","18055","18052"],"item_10001_biblio_info_7":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-11-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageStart":"2105365","bibliographicVolumeNumber":"18","bibliographic_titles":[{},{"bibliographic_title":"Small","bibliographic_titleLang":"en"}]}]},"item_10001_creator_3":{"attribute_name":"Author","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Zhao, Hao"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Xu, Xiushang"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Zhou, Long"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hu, Yunbin"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Huang, Yiming"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Narita, Akimitsu"}],"nameIdentifiers":[{}]}]},"item_10001_description_5":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"Helicene-based therapeutic agents for organelle-targeted photodynamic therapy (PDT) involving both type I and II are challenging and still underexplored. Herein, water-soluble nanoparticles containing twisted double [7]carbohelicene (D7H-NPs) are prepared through self-assembly with 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] by a nanoprecipitation method. D7H-NPs display high water solubility with an average size of 46 ± 2 nm. Notably, D7H-NPs can generate efficient singlet oxygen (1O2) and superoxide anion (O2· −) upon white light irradiation, forming the basis of PDT. Moreover, the typical accumulation in lysosomes of 4T1 cancer cells paves the way to use D7H-NPs for lysosome-targeted cancer phototherapeutics. This paper reports a promising helicene-based phototherapeutic agent involving both type I and II PDT for organelle-targeted biotherapy.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Wiley-VCH GmbH"}]},"item_10001_relation_13":{"attribute_name":"PubMedNo.","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:pmid/34741415","subitem_relation_type_select":"PMID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1002/smll.202105365","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_17":{"attribute_name":"Related site","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://onlinelibrary.wiley.com/doi/10.1002/smll.202105365","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"© 2021 Wiley-VCH GmbH"},{"subitem_rights":"This is the peer reviewed version of the following article: Zhao, H., Xu, X., Zhou, L., Hu, Y., Huang, Y., Narita, A., Water-Soluble Nanoparticles with Twisted Double [7]Carbohelicene for Lysosome-Targeted Cancer Photodynamic Therapy. Small 2022, 18, 2105365., which has been published in final form at https://onlinelibrary.wiley.com/doi/10.1002/smll.202105365. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited."}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1613-6810","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"1613-6829","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"Author's flag","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-11-06"}],"displaytype":"detail","filename":"Water-Soluble_am.pdf","filesize":[{"value":"3.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Water-Soluble_am","url":"https://oist.repo.nii.ac.jp/record/2817/files/Water-Soluble_am.pdf"},"version_id":"2c40972a-f14a-43f7-8e20-35e444fd63ce"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"bioimaging","subitem_subject_scheme":"Other"},{"subitem_subject":"cancer treatment","subitem_subject_scheme":"Other"},{"subitem_subject":"carbohelicene","subitem_subject_scheme":"Other"},{"subitem_subject":"nanoparticles","subitem_subject_scheme":"Other"},{"subitem_subject":"photodynamic therapy","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Water‐Soluble Nanoparticles with Twisted Double [7]Carbohelicene for Lysosome‐Targeted Cancer Photodynamic Therapy","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Water‐Soluble Nanoparticles with Twisted Double [7]Carbohelicene for Lysosome‐Targeted Cancer Photodynamic Therapy","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"31","path":["177"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-10-12"},"publish_date":"2022-10-12","publish_status":"0","recid":"2817","relation_version_is_last":true,"title":["Water‐Soluble Nanoparticles with Twisted Double [7]Carbohelicene for Lysosome‐Targeted Cancer Photodynamic Therapy"],"weko_creator_id":"31","weko_shared_id":31},"updated":"2023-06-26T11:23:25.664190+00:00"}