{"created":"2023-06-26T11:02:03.943845+00:00","id":2835,"links":{},"metadata":{"_buckets":{"deposit":"63c70bc6-0034-4edb-9d62-961ee9a9a214"},"_deposit":{"created_by":22,"id":"2835","owners":[22],"pid":{"revision_id":0,"type":"depid","value":"2835"},"status":"published"},"_oai":{"id":"oai:oist.repo.nii.ac.jp:00002835","sets":["7:235"]},"author_link":[],"item_10006_creator_3":{"attribute_name":"Author","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kato, Mizuki","creatorNameLang":"en"}]}]},"item_10006_date_granted_11":{"attribute_name":"Degree Conferral Date","attribute_value_mlt":[{"subitem_dategranted":"2022-10-31"}]},"item_10006_degree_grantor_9":{"attribute_name":"Degree Conferrral Institution","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"Okinawa Institute of Science and Technology Graduate University  "}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"38005","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"Degree","attribute_value_mlt":[{"subitem_degreename":"Doctor of Philosophy"}]},"item_10006_description_7":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"This project aims to investigate the interrelationship between primary dendrite selection of Purkinje cells and migration of their pre-synaptic partner granule cells during cerebellar development. During development of the cerebellar cortex, each Purkinje cell grows more than three dendritic trees, among which a primary tree is selected to develop further, whereas others completely retract. Experimental studies suggested that this selection process is coordinated by physical and synaptic interactions with granule cells. However, technical limitations hinder a continuous observation on multiple populations of the cells. To reveal the mechanism underlying this selection process, we constructed a computational model of dendritic development and granule cell migration, using a new computational framework, NeuroDevSim. Comparisons of the resulting morphologies from the model demonstrated the roles of the selection stage in regulating the growth of the selected primary trees. This thesis presents the first computational model that simultaneously simulates growing Purkinje cells and the dynamics of granule cell migration, revealing the role of physical and synaptic interactions upon dendritic selection. Development of the model is expected to provide new insights in the development of neonatal Purkinje cells and help to track down how cerebellar cortex develops into a normal or abnormal structure.","subitem_description_type":"Other"}]},"item_10006_dissertation_number_12":{"attribute_name":"Degree Referral Number","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第107号 "}]},"item_10006_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15102/1394.00002565","subitem_identifier_reg_type":"JaLC"}]},"item_10006_rights_13":{"attribute_name":"Copyright Information","attribute_value_mlt":[{"subitem_rights":"© 2022 The Author"}]},"item_10006_text_24":{"attribute_name":"Exam Date","attribute_value_mlt":[{"subitem_text_value":"2022-07-21"}]},"item_10006_version_type_18":{"attribute_name":"Version Format","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-11-10"}],"displaytype":"detail","filename":"KatoFullText.pdf","filesize":[{"value":"24.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KatoFullText","objectType":"fulltext","url":"https://oist.repo.nii.ac.jp/record/2835/files/KatoFullText.pdf"},"version_id":"2c7de7b9-b31d-49c2-ab3e-23e21c120ae7"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-11-10"}],"displaytype":"detail","filename":"KatoFinalExamAbstract.pdf","filesize":[{"value":"42.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KatoFinalExamAbstract","objectType":"abstract","url":"https://oist.repo.nii.ac.jp/record/2835/files/KatoFinalExamAbstract.pdf"},"version_id":"6a02f29b-5fca-4df1-b416-95f928695060"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"小脳発生における顆粒細胞移動とプルキンエ細胞樹状突起選択の計算モデル","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"小脳発生における顆粒細胞移動とプルキンエ細胞樹状突起選択の計算モデル","subitem_title_language":"ja"},{"subitem_title":"A Computational Model of Granule Cell Migration and Purkinje Cell Primary Dendrite Selection during Cerebellar Development","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"22","path":["235"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-11-10"},"publish_date":"2022-11-10","publish_status":"0","recid":"2835","relation_version_is_last":true,"title":["小脳発生における顆粒細胞移動とプルキンエ細胞樹状突起選択の計算モデル"],"weko_creator_id":"22","weko_shared_id":-1},"updated":"2023-09-01T02:33:29.362081+00:00"}