{"created":"2023-06-26T11:00:05.588583+00:00","id":291,"links":{},"metadata":{"_buckets":{"deposit":"42cd90a0-1e84-4112-b08d-7a4af9fac667"},"_deposit":{"created_by":26,"id":"291","owners":[26],"pid":{"revision_id":0,"type":"depid","value":"291"},"status":"published"},"_oai":{"id":"oai:oist.repo.nii.ac.jp:00000291","sets":["6:43"]},"author_link":["954","958","957","959","955","956"],"item_10001_biblio_info_7":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-04-05","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"45962","bibliographicVolumeNumber":"7","bibliographic_titles":[{},{"bibliographic_title":"Scientific Reports","bibliographic_titleLang":"en"}]}]},"item_10001_creator_3":{"attribute_name":"Author","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Iribarne, Maria"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nishiwaki, Yuko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakamura, Shohei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Araragi, Masato"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Oguri, Eri"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Masai, Ichiro"}],"nameIdentifiers":[{}]}]},"item_10001_description_5":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"Genetic mutations in aryl hydrocarbon receptor interacting protein-like 1 (AIPL1) cause photoreceptor\ndegeneration associated with Leber congenital amaurosis 4 (LCA4) in human patients. Here we report\nretinal phenotypes of a zebrafish aipl1 mutant, gold rush (gosh). In zebrafish, there are two aipl1 genes,\naipl1a and aipl1b, which are expressed mainly in rods and cones, respectively. The gosh mutant gene\nencodes cone-specific aipl1, aipl1b. Cone photoreceptors undergo progressive degeneration in the gosh\nmutant, indicating that aipl1b is required for cone survival. Furthermore, the cone-specific subunit of\ncGMP phosphodiesterase 6 (Pde6c) is markedly decreased in the gosh mutant, and the gosh mutation\ngenetically interacts with zebrafish pde6c mutation eclipse (els). These data suggest that Aipl1 is\nrequired for Pde6c stability and function. In addition to Pde6c, we found that zebrafish cone-specific\nguanylate cyclase, zGc3, is also decreased in the gosh and els mutants. Furthermore, zGc3 knockdown\nembryos showed a marked reduction in Pde6c. These observations illustrate the interdependence of\ncGMP metabolism regulators between Aipl1, Pde6c, and Gc3 in photoreceptors.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":" Springer Nature"}]},"item_10001_relation_13":{"attribute_name":"PubMedNo.","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:pmid/28378769","subitem_relation_type_select":"PMID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1038/srep45962","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_17":{"attribute_name":"Related site","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.nature.com/articles/srep45962","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"© 2017 The Author(s) ."}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2045-2322","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"Author's flag","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-04-04"}],"displaytype":"detail","filename":"srep45962.pdf","filesize":[{"value":"2.9 MB"}],"format":"application/pdf","license_note":"Creative Commons Attribution 4.0 International  \n(http://creativecommons.org/licenses/by/4.0/)","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"srep45962","url":"https://oist.repo.nii.ac.jp/record/291/files/srep45962.pdf"},"version_id":"7223b9c6-b807-497c-9170-056b08e118cc"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Aipl1 is required for cone photoreceptor function and survival through the stability of Pde6c and Gc3 in zebrafish","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Aipl1 is required for cone photoreceptor function and survival through the stability of Pde6c and Gc3 in zebrafish","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"26","path":["43"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-02-27"},"publish_date":"2018-02-27","publish_status":"0","recid":"291","relation_version_is_last":true,"title":["Aipl1 is required for cone photoreceptor function and survival through the stability of Pde6c and Gc3 in zebrafish"],"weko_creator_id":"26","weko_shared_id":26},"updated":"2023-06-26T12:09:35.542886+00:00"}