@article{oai:oist.repo.nii.ac.jp:00000813,
 author = {Khrameeva, Ekaterina and Kurochkin, Ilia and Bozek, Katarzyna and Giavalisco, Patrick and Khaitovich, Philipp},
 issue = {8},
 journal = {Molecular Biology and Evolution},
 month = {May},
 note = {Lipids are essential structural and functional components of cells. Little is known, however, about the evolution of lipid composition in different tissues. Here, we report a large-scale analysis of the lipidome evolution in six tissues of 32 species representing primates, rodents, and bats. While changes in genes' sequence and expression accumulate proportionally to the phylogenetic distances, <2% of the lipidome evolves this way. Yet, lipids constituting this 2% cluster in specific functions shared among all tissues. Among species, human show the largest amount of species-specific lipidome differences. Many of the uniquely human lipidome features localize in the brain cortex and cluster in specific pathways implicated in cognitive disorders.},
 pages = {1947--1957},
 title = {Lipidome Evolution in Mammalian Tissues},
 volume = {35},
 year = {2018}
}