{"created":"2023-06-26T11:00:20.860935+00:00","id":814,"links":{},"metadata":{"_buckets":{"deposit":"b196584f-96ed-4a3e-a9c0-7941f1dcaa11"},"_deposit":{"created_by":27,"id":"814","owners":[27],"pid":{"revision_id":0,"type":"depid","value":"814"},"status":"published"},"_oai":{"id":"oai:oist.repo.nii.ac.jp:00000814","sets":["6:66"]},"author_link":["4189","4190","4191","4192","4187","4188"],"item_10001_biblio_info_7":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-06-20","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"2733","bibliographicPageStart":"2723","bibliographicVolumeNumber":"8","bibliographic_titles":[{},{"bibliographic_title":"G3: Genes, Genomes, Genetics","bibliographic_titleLang":"en"}]}]},"item_10001_creator_3":{"attribute_name":"Author","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Suma, Michiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kitagawa, Teppei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakase, Yukiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakazawa, Norihiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yanagida, Mitsuhiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsumoto, Tomohiro"}],"nameIdentifiers":[{}]}]},"item_10001_description_5":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"The centromere is a chromosomal locus where a microtubule attachment site, termed kinetochore, is assembled in mitosis. In most eukaryotes, with the exception of holocentric species, each chromosome contains a single distinct centromere. A chromosome with an additional centromere undergoes successive rounds of anaphase bridge formation and breakage, or triggers a cell cycle arrest imposed by DNA damage and replication checkpoints. We report here a study in Schizosaccharomyces pombe to characterize a mutant (cnp3-1) in a gene encoding a homolog of mammalian centromere-specific protein, CENP-C. At the restrictive temperature 36 degrees , the Cnp3-1 mutant protein loses its localization at the centromere. In the cnp3-1 mutant, the level of the Cnp1 (a homolog of a centromere-specific histone CENP-A) also decreases at the centromere. Interestingly, the cnp3-1 mutant is prone to promiscuous accumulation of Cnp1 at non-centromeric regions, when Cnp1 is present in excess. Unlike the wild type protein, Cnp3-1 mutant protein is found at the sites of promiscuous accumulation of Cnp1, suggesting that Cnp3-1 may stabilize or promote accumulation of Cnp1 at non-centromeric regions. From these results, we infer the role of Cnp3 in restricting the site of accumulation of Cnp1 and thus to prevent formation of de novo centromeres.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"The Genetics Society of America"}]},"item_10001_relation_13":{"attribute_name":"PubMedNo.","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:pmid/29925533","subitem_relation_type_select":"PMID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1534/g3.118.200486","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_17":{"attribute_name":"Related site","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.g3journal.org/content/8/8/2723","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"© 2018 Suma et al."}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2160-1836","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"Author's flag","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-03-04"}],"displaytype":"detail","filename":"2723.full.pdf","filesize":[{"value":"2.1 MB"}],"format":"application/pdf","license_note":"Creative Commons\nAttribution 4.0 International\n(https://creativecommons.org/licenses/by/4.0/)","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2723.full","url":"https://oist.repo.nii.ac.jp/record/814/files/2723.full.pdf"},"version_id":"9956d4a4-2245-42df-9c1c-ead98f5dd98b"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Fission Yeast CENP-C (Cnp3) Plays a Role in Restricting the Site of CENP-A Accumulation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Fission Yeast CENP-C (Cnp3) Plays a Role in Restricting the Site of CENP-A Accumulation","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"27","path":["66"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-03-04"},"publish_date":"2019-03-04","publish_status":"0","recid":"814","relation_version_is_last":true,"title":["Fission Yeast CENP-C (Cnp3) Plays a Role in Restricting the Site of CENP-A Accumulation"],"weko_creator_id":"27","weko_shared_id":27},"updated":"2023-06-26T12:02:49.135962+00:00"}