{"created":"2023-06-26T11:00:20.994968+00:00","id":817,"links":{},"metadata":{"_buckets":{"deposit":"a33d9258-f450-458b-a83c-d7b26ce87683"},"_deposit":{"created_by":22,"id":"817","owners":[22],"pid":{"revision_id":0,"type":"depid","value":"817"},"status":"published"},"_oai":{"id":"oai:oist.repo.nii.ac.jp:00000817","sets":["7:180"]},"author_link":[],"item_10006_creator_2":{"attribute_name":"Author","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"五十嵐, 正和","creatorNameLang":"ja"}]}]},"item_10006_creator_3":{"attribute_name":"Author","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Igarashi, Masakazu","creatorNameLang":"en"}]}]},"item_10006_date_granted_11":{"attribute_name":"Degree Conferral Date","attribute_value_mlt":[{"subitem_dategranted":"2019-02-28"}]},"item_10006_degree_grantor_9":{"attribute_name":"Degree Conferrral Institution","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"Okinawa Institute of Science and Technology Graduate University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"38005","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"Degree","attribute_value_mlt":[{"subitem_degreename":"Doctor of Philosophy"}]},"item_10006_description_7":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"Bimanual coordination – in which both hands work together to achieve a goal – is crucial for basic needs of life, such as gathering and feeding. The mammalian body has a left and right side which is often symmetrically shaped, but raises the question of how does the brain organize two sides of our body in a coordinated manner. The overall aim of this thesis is to better-understand neural mechanism of bimanual coordination. Bimanual coordination is highly developed in primates, where it has been most extensively studied. Rodents also exhibit remarkable dexterity and coordination of forelimbs during food handling and consumption. However, rodents have been less commonly used in the study of bimanual coordination because of limited quantitative measuring techniques. To study the neural mechanism of bimanual coordination using rodents, therefore, first requires a method to measure and classify bimanual movements. In this thesis, I propose a high-resolution tracking system that enables kinematic analysis of rat forelimb movements. The system quantifies forelimb movements bilaterally in head-fixed rats during food handling and consumption. Forelimb movements occurring naturally during feeding were encoded as continuous 3-D trajectories. The trajectories were then automatically segmented and analyzed, using a novel algorithm, according to the laterality of movement speed or the asymmetry of movement direction across the forelimbs. Bilateral forelimb movements were frequently observed during spontaneous food handling. Both symmetry and asymmetry in movement direction were observed, with symmetric bilateral movements quantitatively more common. Using the proposed method, I further investigated a key hypothesis that the corpus callosum, the thickest commissure connecting two cerebral cortices, mediates bimanual movements. I performed pharmacological blockade of the anterior corpus callosum (aCC) in which commissures from cortical forelimb motor areas are reciprocally connected. The kinematic analysis of bimanual coordination during food handling revealed that the frequency of occurrence of symmetric bimanual movements was reduced by aCC inhibition. In counterpart, asymmetric bimanual movements were increased. Other global scales of motor skills, such as mean food drop rate, and mean consumption time remained unchanged. Bilateral multiunit recordings from corresponding cortical areas showed positively correlated activity patterns in the large majority of interacting pairs. The present study also found that the putative excitatory neurons were also positively correlated with putative inhibitory neurons in the opposite hemisphere, suggesting interhemispheric inhibition via inhibitory neurons. Collectively, these results suggest that the symmetric bimanual movements in rodents are modulated by the anterior corpus callosum via both excitatory and inhibitory connections of two motor cortices.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_10006_dissertation_number_12":{"attribute_name":"Degree Referral Number","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第26号"}]},"item_10006_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15102/1394.00000740","subitem_identifier_reg_type":"JaLC"}]},"item_10006_rights_13":{"attribute_name":"Copyright Information","attribute_value_mlt":[{"subitem_rights":"©2019 The Author."}]},"item_10006_text_24":{"attribute_name":"Exam Date","attribute_value_mlt":[{"subitem_text_value":"2019-01-16"}]},"item_10006_version_type_18":{"attribute_name":"Version Format","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-03-04"}],"displaytype":"detail","filename":"Full_Text.pdf","filesize":[{"value":"11.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Full_Text","objectType":"fulltext","url":"https://oist.repo.nii.ac.jp/record/817/files/Full_Text.pdf"},"version_id":"70136922-c2e2-4a27-a661-2b789d68bab0"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-03-04"}],"displaytype":"detail","filename":"Final_Exam_Abstract.pdf","filesize":[{"value":"42.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Final_Exam_Abstract","objectType":"abstract","url":"https://oist.repo.nii.ac.jp/record/817/files/Final_Exam_Abstract.pdf"},"version_id":"c3c619cf-9a4f-4cf1-83e8-e9fc875fc4d0"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"ラットの両側性協調運動における脳梁を介した左右皮質接続の役割の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ラットの両側性協調運動における脳梁を介した左右皮質接続の役割の解明","subitem_title_language":"ja"},{"subitem_title":"The role of interhemispheric cortico-cortical connections in bimanual coordination in the rat","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"22","path":["180"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-03-04"},"publish_date":"2019-03-04","publish_status":"0","recid":"817","relation_version_is_last":true,"title":["ラットの両側性協調運動における脳梁を介した左右皮質接続の役割の解明"],"weko_creator_id":"22","weko_shared_id":-1},"updated":"2023-08-30T05:52:59.565967+00:00"}