@article{oai:oist.repo.nii.ac.jp:00000858, author = {Ji, Wei and Zhang, Shijin and Yukawa, Sachie and Onomura, Shogo and Sasaki, Toshio and Miyazawa, Kun'ichi and Zhang, Ye}, issue = {14}, journal = {Angewandte Chemie International Edition}, month = {Feb}, note = {The extracellular matrix (ECM) is the natural fibrous scaffold that regulates cell behavior in a hierarchical manner. By mimicking the dynamic and reciprocal interactions between ECM and cells, higher-order molecular self-assembly (SA), mediated through the dynamic growth of scaffold-like nanostructures assembled by different molecular components, was developed. Designed and synthesized were two self-sorted coumarin-based gelators, a peptide molecule and a benzoate molecule, which self-assemble into nanofibers and nanobelts, respectively, with different dynamic profiles. Upon the dynamic growth of the fibrous scaffold assembled from peptide gelators, nanobelts assembled from benzoate gelators transform into a layer-by-layer nanosheet, reaching ninefold increase in height. By using light and an enzyme, the spatial-temporal growth of the scaffold can be modified, leading to in situ height regulation of the higher-order architecture.}, pages = {3636--3640}, title = {Regulating Higher-Order Organization through the Synergy of Two Self-Sorted Assemblies}, volume = {57}, year = {2018} }