{"created":"2023-06-26T11:00:23.588964+00:00","id":871,"links":{},"metadata":{"_buckets":{"deposit":"ab031aab-a9d6-4609-b5dd-98204fb46ffd"},"_deposit":{"created_by":28,"id":"871","owners":[28],"pid":{"revision_id":0,"type":"depid","value":"871"},"status":"published"},"_oai":{"id":"oai:oist.repo.nii.ac.jp:00000871","sets":["6:66"]},"author_link":["4485","4487","4488","4489","4490","4486"],"item_10001_biblio_info_7":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-08-15","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageStart":"eaat5685","bibliographicVolumeNumber":"4","bibliographic_titles":[{},{"bibliographic_title":"Science Advances","bibliographic_titleLang":"en"}]}]},"item_10001_creator_3":{"attribute_name":"Author","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sajiki, Kenichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tahara, Yuria"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Uehara, Lisa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sasaki, Toshio"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Pluskal, Tomáš"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yanagida, Mitsuhiro"}],"nameIdentifiers":[{}]}]},"item_10001_description_5":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"Quiescent (G0 phase) cells must maintain mitotic competence (MC) to restart the cell cycle. This is essential for reproduction in unicellular organisms and also for development and cell replacement in higher organisms. Recently, suppression of MC has gained attention as a possible therapeutic strategy for cancer. Using a Schizosaccharomyces pombe deletion-mutant library, we identified 85 genes required to maintain MC during the G0 phase induced by nitrogen deprivation. G0 cells must recycle proteins and RNA, governed by anabolism, catabolism, transport, and availability of small molecules such as antioxidants. Protein phosphatases are also essential to maintain MC. In particular, Nem1-Spo7 protects the nucleus from autophagy by regulating Ned1, a lipin. These genes, designated GZE (G-Zero Essential) genes, reveal the landscape of genetic regulation of MC.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"American Association for the Advancement of Science"}]},"item_10001_relation_13":{"attribute_name":"PubMedNo.","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:pmid/30116786 ","subitem_relation_type_select":"PMID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1126/sciadv.aat5685","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://creativecommons.org/licenses/by/4.0/"}]}]},"item_10001_relation_17":{"attribute_name":"Related site","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://advances.sciencemag.org/content/4/8/eaat5685","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"© 2018 The Author(s), some rights reserved; exclusive licensee American Association for the Advancement of Science."}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2375-2548","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"Author's flag","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-05-16"}],"displaytype":"detail","filename":"Sajiki-2018-Genetic regulation of mitotic comp.pdf","filesize":[{"value":"2.4 MB"}],"format":"application/pdf","license_note":"Creative Commons\nAttribution 4.0 International\n(https://creativecommons.org/licenses/by/4.0/)","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Sajiki-2018-Genetic regulation of mitotic comp","url":"https://oist.repo.nii.ac.jp/record/871/files/Sajiki-2018-Genetic regulation of mitotic comp.pdf"},"version_id":"c51985f9-e085-4647-8e62-ef38f6a1ebdc"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Genetic regulation of mitotic competence in G0quiescent cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Genetic regulation of mitotic competence in G0quiescent cells","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"28","path":["66"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-05-16"},"publish_date":"2019-05-16","publish_status":"0","recid":"871","relation_version_is_last":true,"title":["Genetic regulation of mitotic competence in G0quiescent cells"],"weko_creator_id":"28","weko_shared_id":28},"updated":"2023-06-26T12:01:33.747683+00:00"}