@article{oai:oist.repo.nii.ac.jp:00000875,
 author = {Wang, Bing and Tanaka, Kaoru and Ninomiya, Yasuharu and Maruyama, Kouichi and Varès, Guillaume and Katsube, Takanori and Murakami, Masahiro and Liu, Cuihua and Fujimori, Akira and Fujita, Kazuko and Liu, Qiang and Eguchi-Kasai, Kiyomi and Nenoi, Mitsuru},
 issue = {3},
 journal = {Dose-Response},
 month = {Aug},
 note = {The existence of radiation-induced adaptive response (AR) was reported in varied biosystems. In mice, the first in vivo AR model was established using X-rays as both the priming and the challenge doses and rescue of bone marrow death as the end point. The underlying mechanism was due to the priming radiation-induced resistance in the blood-forming tissues. In a series of investigations, we further demonstrated the existence of AR using different types of ionizing radiation (IR) including low linear energy transfer (LET) X-rays and high LET heavy ion. In this article, we validated hematopoietic stem cells/hematopoietic progenitor cells (HSCs/HPCs) measured as endogenous colony-forming units-spleen (CFU-S) under AR inducible and uninducible conditions using combination of different types of IR. We confirmed the consistency of increased CFU-S number change with the AR inducible condition. These findings suggest that AR in mice induced by different types of IR would share at least in part a common underlying mechanism, the priming IR-induced resistance in the blood-forming tissues, which would lead to a protective effect on the HSCs/HPCs and play an important role in rescuing the animals from bone marrow death. These findings provide a new insight into the mechanistic study on AR in vivo.},
 title = {Increased Hematopoietic Stem Cells/Hematopoietic Progenitor Cells Measured as Endogenous Spleen Colonies in Radiation-Induced Adaptive Response in Mice (Yonezawa Effect)},
 volume = {16},
 year = {2018}
}