{"created":"2023-06-26T11:00:26.122366+00:00","id":925,"links":{},"metadata":{"_buckets":{"deposit":"b610dfda-5629-44cd-b686-4413328778e9"},"_deposit":{"created_by":28,"id":"925","owners":[28],"pid":{"revision_id":0,"type":"depid","value":"925"},"status":"published"},"_oai":{"id":"oai:oist.repo.nii.ac.jp:00000925","sets":["6:165","6:33"]},"author_link":["5019","5022","5025","5018","5017","5026","5024","5020","5021","5023","5016"],"item_10001_biblio_info_7":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-12-17","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageStart":"5344","bibliographicVolumeNumber":"9","bibliographic_titles":[{},{"bibliographic_title":"Nature Communications","bibliographic_titleLang":"en"}]}]},"item_10001_creator_3":{"attribute_name":"Author","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Koizumi, Shin-ichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sasaki, Daiki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hsieh, Tsung-Han"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Taira, Naoyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Arakaki, Nana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamasaki, Shinichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Wang, Ke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sarkar, Shukla"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shirahata, Hiroki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miyagi, Mio"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishikawa, Hiroki"}],"nameIdentifiers":[{}]}]},"item_10001_description_5":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"Foxp3-expressing CD4(+) regulatory T (Treg) cells need to differentiate into effector Treg (eTreg) cells to maintain immune homeostasis. T-cell receptor (TCR)-dependent induction of the transcription factor IRF4 is essential for eTreg differentiation, but how IRF4 activity is regulated in Treg cells is still unclear. Here we show that the AP-1 transcription factor, JunB, is expressed in eTreg cells and promotes an IRF4-dependent transcription program. Mice lacking JunB in Treg cells develop multi-organ autoimmunity, concomitant with aberrant activation of T helper cells. JunB promotes expression of Treg effector molecules, such as ICOS and CTLA4, in BATF-dependent and BATF-independent manners, and is also required for homeostasis and suppressive functions of eTreg. Mechanistically, JunB facilitates the accumulation of IRF4 at a subset of IRF4 target sites, including those located near Icos and Ctla4. Thus, JunB is a critical regulator of IRF4-dependent Treg effector programs, highlighting important functions for AP-1 in Treg-mediated immune homeostasis.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Nature Research"}]},"item_10001_relation_13":{"attribute_name":"PubMedNo.","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:pmid/30559442","subitem_relation_type_select":"PMID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1038/s41467-018-07735-4","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://creativecommons.org/licenses/by/4.0/"}]}]},"item_10001_relation_17":{"attribute_name":"Related site","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.nature.com/articles/s41467-018-07735-4","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"© 2018 The Author(s)."}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2041-1723","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"Author's flag","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-06-10"}],"displaytype":"detail","filename":"Koizumi-2018-JunB regulates homeostasis and su.pdf","filesize":[{"value":"2.5 MB"}],"format":"application/pdf","license_note":"Creative Commons\nAttribution 4.0 International​\n(https://creativecommons.org/licenses/by/4.0/)","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Koizumi-2018-JunB regulates homeostasis and su","url":"https://oist.repo.nii.ac.jp/record/925/files/Koizumi-2018-JunB regulates homeostasis and su.pdf"},"version_id":"6960c4b5-7b07-400e-9f79-3536c9faca27"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"JunB regulates homeostasis and suppressive functions of effector regulatory T cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"JunB regulates homeostasis and suppressive functions of effector regulatory T cells","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"28","path":["33","165"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-06-10"},"publish_date":"2019-06-10","publish_status":"0","recid":"925","relation_version_is_last":true,"title":["JunB regulates homeostasis and suppressive functions of effector regulatory T cells"],"weko_creator_id":"28","weko_shared_id":28},"updated":"2023-06-26T12:00:11.892157+00:00"}