{"created":"2023-06-26T11:00:26.763677+00:00","id":936,"links":{},"metadata":{"_buckets":{"deposit":"ec79f696-35e7-4d99-b3ac-e37c7e09443b"},"_deposit":{"created_by":28,"id":"936","owners":[28],"pid":{"revision_id":0,"type":"depid","value":"936"},"status":"published"},"_oai":{"id":"oai:oist.repo.nii.ac.jp:00000936","sets":["6:43"]},"author_link":["5144","5142","5143","5145","5146"],"item_10001_biblio_info_7":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-10-15","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"20","bibliographicPageStart":"dev170282","bibliographicVolumeNumber":"145","bibliographic_titles":[{},{"bibliographic_title":"Development","bibliographic_titleLang":"en"}]}]},"item_10001_creator_3":{"attribute_name":"Author","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Mochizuki, Toshiaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kojima, Yutaka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nishiwaki, Yuko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Harakuni, Tetsuya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Masai, Ichiro"}],"nameIdentifiers":[{}]}]},"item_10001_description_5":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"In vertebrate lens, lens epithelial cells cover the anterior half of the lens fiber core. Lens epithelial cells proliferate, move posteriorly and start to differentiate into lens fiber cells at the lens equator. Although FGF signaling promotes this equatorial commencement of lens fiber differentiation, the underlying mechanism is not fully understood. Here, we show that lens epithelial cells abnormally enter lens fiber differentiation without passing through the equator in zebrafish vps45 mutants. VPS45 belongs to the Sec1/Munc18-like protein family and promotes endosome trafficking, which differentially modulates signal transduction. Ectopic lens fiber differentiation in vps45 mutants does not depend on FGF, but is mediated through activation of TGFbeta signaling and inhibition of canonical Wnt signaling. Thus, VPS45 normally suppresses lens fiber differentiation in the anterior region of lens epithelium by modulating TGFbeta and canonical Wnt signaling pathways. These data indicate a novel role of endosome trafficking to ensure equator-dependent commencement of lens fiber differentiation.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Company of Biologists Ltd"}]},"item_10001_relation_13":{"attribute_name":"PubMedNo.","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:pmid/30322969 ","subitem_relation_type_select":"PMID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1242/dev.170282","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://creativecommons.org/licenses/by/3.0/"}]}]},"item_10001_relation_17":{"attribute_name":"Related site","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://dev.biologists.org/content/145/20/dev170282","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"© 2018 The Company of Biologists Ltd."}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0950-1991","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"1477-9129","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"Author's flag","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-06-13"}],"displaytype":"detail","filename":"Mochizuki-2018-Endocytic trafficking factor VP.pdf","filesize":[{"value":"14.8 MB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"Mochizuki-2018-Endocytic trafficking factor VP","url":"https://oist.repo.nii.ac.jp/record/936/files/Mochizuki-2018-Endocytic trafficking factor VP.pdf"},"version_id":"1d8e30df-e03a-4ad3-b083-615a7e416651"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Endocytic trafficking factor VPS45 is essential for spatial regulation of lens fiber differentiation in zebrafish","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Endocytic trafficking factor VPS45 is essential for spatial regulation of lens fiber differentiation in zebrafish","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"28","path":["43"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-06-13"},"publish_date":"2019-06-13","publish_status":"0","recid":"936","relation_version_is_last":true,"title":["Endocytic trafficking factor VPS45 is essential for spatial regulation of lens fiber differentiation in zebrafish"],"weko_creator_id":"28","weko_shared_id":28},"updated":"2023-06-26T11:59:54.251348+00:00"}