@article{oai:oist.repo.nii.ac.jp:00000979, author = {Cheung, Martin and Adaniya, Hidehito and Cassidy, Cathal and Yamashita, Masao and Li, Kun-Lung and Taba, Seita and Shintake, Tsumoru}, issue = {1}, journal = {Journal of Structural Biology}, month = {Jul}, note = {For many macromolecular complexes, the inability to uniformly disperse solubilized specimen particles within vitreous ice films precludes their analysis by cryo-electron microscopy (cryo-EM). Here, we introduce a sample preparation process using “perpetually-hydrated” graphene oxide flakes as particle support films, and report vastly improved specimen dispersion. The new method introduced in this study incorporates hydrated graphene oxide flakes into a standard sample preparation regime, without the need for additional tools or devices, making it a cost-effective and easily adoptable alternative to currently available sample preparation approaches.}, pages = {75--79}, title = {Improved sample dispersion in cryo-EM using “perpetually-hydrated” graphene oxide flakes}, volume = {204}, year = {2018} }