{"created":"2023-06-26T11:00:29.835573+00:00","id":998,"links":{},"metadata":{"_buckets":{"deposit":"91924867-c5b9-41c0-8dc4-24a955d3b8c5"},"_deposit":{"created_by":28,"id":"998","owners":[28],"pid":{"revision_id":0,"type":"depid","value":"998"},"status":"published"},"_oai":{"id":"oai:oist.repo.nii.ac.jp:00000998","sets":["6:171"]},"author_link":["5491","5493","5488","5490","5484","5485","5483","5492","5482","5487","5486","5489"],"item_10001_biblio_info_7":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-02-28","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageStart":"981","bibliographicVolumeNumber":"10","bibliographic_titles":[{},{"bibliographic_title":"Nature Communications","bibliographic_titleLang":"en"}]}]},"item_10001_creator_3":{"attribute_name":"Author","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nishimura, Koutarou"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Johmura, Yoshikazu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Deguchi, Katashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Jiang, Zixian"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Uchida, Kazuhiko S. K."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suzuki, Narumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shimada, Midori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Chiba, Yoshie"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hirota, Toru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshimura, Shige H."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kono, Keiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakanishi, Makoto"}],"nameIdentifiers":[{}]}]},"item_10001_description_5":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"Animal cells undergo rapid rounding during mitosis, ensuring proper chromosome segregation, during which an outward rounding force abruptly increases upon prometaphase entry and is maintained at a constant level during metaphase. Initial cortical tension is generated by the actomyosin system to which both myosin motors and actin network architecture contribute. However, how cortical tension is maintained and its physiological significance remain unknown. We demonstrate here that Cdk1-mediated phosphorylation of DIAPH1 stably maintains cortical tension after rounding and inactivates the spindle assembly checkpoint (SAC). Cdk1 phosphorylates DIAPH1, preventing profilin1 binding to maintain cortical tension. Mutation of DIAPH1 phosphorylation sites promotes cortical F-actin accumulation, increases cortical tension, and delays anaphase onset due to SAC activation. Measurement of the intra-kinetochore length suggests that Cdk1-mediated cortex relaxation is indispensable for kinetochore stretching. We thus uncovered a previously unknown mechanism by which Cdk1 coordinates cortical tension maintenance and SAC inactivation at anaphase onset.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Nature Research"}]},"item_10001_relation_13":{"attribute_name":"PubMedNo.","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:pmid/30816115 ","subitem_relation_type_select":"PMID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1038/s41467-019-08957-w","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://creativecommons.org/licenses/by/4.0/"}]}]},"item_10001_relation_17":{"attribute_name":"Related site","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.nature.com/articles/s41467-019-08957-w","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"© 2019 The Author(s)."}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2041-1723","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"Author's flag","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-07-08"}],"displaytype":"detail","filename":"Nishimura-2019-Cdk1-mediated DIAPH1 phosphoryl.pdf","filesize":[{"value":"2.5 MB"}],"format":"application/pdf","license_note":"Creative Commons​\nAttribution 4.0 International​\n(https://creativecommons.org/licenses/by/4.0/)","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Nishimura-2019-Cdk1-mediated DIAPH1 phosphoryl","url":"https://oist.repo.nii.ac.jp/record/998/files/Nishimura-2019-Cdk1-mediated DIAPH1 phosphoryl.pdf"},"version_id":"d0c4c1dd-5f72-48f2-88a4-a3fb17b2b3ed"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Cdk1-mediated DIAPH1 phosphorylation maintains metaphase cortical tension and inactivates the spindle assembly checkpoint at anaphase","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Cdk1-mediated DIAPH1 phosphorylation maintains metaphase cortical tension and inactivates the spindle assembly checkpoint at anaphase","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"28","path":["171"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-07-08"},"publish_date":"2019-07-08","publish_status":"0","recid":"998","relation_version_is_last":true,"title":["Cdk1-mediated DIAPH1 phosphorylation maintains metaphase cortical tension and inactivates the spindle assembly checkpoint at anaphase"],"weko_creator_id":"28","weko_shared_id":28},"updated":"2023-06-26T11:58:52.855915+00:00"}