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Self-delivery of N-hydroxylethyl peptide assemblies to the cytosol inducing endoplasmic reticulum dilation in cancer cells
https://oist.repo.nii.ac.jp/records/1209
https://oist.repo.nii.ac.jp/records/12093ba9bc25-dfee-45a7-9aa4-306fb6291724
名前 / ファイル | ライセンス | アクション |
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chem comm SJZ (3.5 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-02-28 | |||||
タイトル | ||||||
タイトル | Self-delivery of N-hydroxylethyl peptide assemblies to the cytosol inducing endoplasmic reticulum dilation in cancer cells | |||||
言語 | en | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Zhang, Shijin
× Zhang, Shijin× Hu, Xunwu× Mang, Dingze× Sasaki, Toshio× Zhang, Ye |
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書誌情報 |
en : Chemical Communications 巻 55, 号 52, p. 7474-7477, 発行日 2019-06-11 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Inspired by clinical studies on alcohol abuse induced endoplasmic reticulum disruption, we designed a N-hydroxylethyl peptide assembly to regulate the ER stress response in cancer cells. Upon coupling with a coumarin derivative via an ester linkage, a prodrug was synthesized to promote esterase-facilitated self-delivery of N-hydroxylethyl peptide assemblies around the ER, inducing ER dilation. Following this, ER-specific apoptosis was effectively and efficiently activated in various types of cancer cells including drug resistant and metastatic ones. | |||||
出版者 | ||||||
出版者 | Royal Society of Chemistry | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1359-7345 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1364-548X | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/31184664 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1039/C9CC03460A | |||||
権利 | ||||||
権利情報 | © 2019 The Royal Society of Chemistry | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://pubs.rsc.org/en/content/articlelanding/2019/CC/C9CC03460A#!divAbstract | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa |